Repair strategies for injured peripheral nerve: Review

Compromised functional regains in about half of the patients following surgical nerve repair pose a serious socioeconomic burden to the society. Although surgical strategies such as end-to-end neurorrhaphy, nerve grafting and nerve transfer are widely applied in distal injuries leading to optimal re...

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Bibliographic Details
Published in:Life sciences (1973) 2020-02, Vol.243, p.117308-117308, Article 117308
Main Authors: Raza, Chand, Riaz, Hasib Aamir, Anjum, Rabia, Shakeel, Noor ul Ain
Format: Article
Language:English
Subjects:
Animals
Axon guidance
Axons
Biocompatible Materials
Biomedical engineering
Endothelial cells
Extracellular matrix
Fabrication
Humans
Injuries
Nerve guidance conduits
Nerve Regeneration - physiology
Nerve vasculature
Peripheral Nerve Injuries - therapy
Peripheral nerves
Polymers
Regeneration
Repair
Surgical nerve repair
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Summary:Compromised functional regains in about half of the patients following surgical nerve repair pose a serious socioeconomic burden to the society. Although surgical strategies such as end-to-end neurorrhaphy, nerve grafting and nerve transfer are widely applied in distal injuries leading to optimal recovery; however in proximal nerve defects functional outcomes remain unsatisfactory. Biomedical engineering approaches unite the efforts of the surgeons, engineers and biologists to develop regeneration facilitating structures such as extracellular matrix based supportive polymers and tubular nerve guidance channels. Such polymeric structures provide neurotrophic support from injured nerve stumps, retard the fibrous tissue infiltration and guide regenerating axons to appropriate targets. The development and application of nerve guidance conduits (NGCs) to treat nerve gap injuries offer clinically relevant and feasible solutions. Enhanced understanding of the nerve regeneration processes and advances in NGCs design, polymers and fabrication strategies have led to developing modern NGCs with superior regeneration-conducive capacities. Current review focuses on the advances in surgical and engineering approaches to treat peripheral nerve injuries. We suggest the incorporation of endothelial cell growth promoting cues and factors into the NGC interior for its possible enhancement effects on the axonal regeneration process that may result in substantial functional outcomes. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2020.117308