A Risk Score Including Carotid Plaque Inflammation and Stenosis Severity Improves Identification of Recurrent Stroke

BACKGROUND AND PURPOSE—In randomized trials of symptomatic carotid endarterectomy, only modest benefit occurred in patients with moderate stenosis and important subgroups experienced no benefit. Carotid plaque F-fluorodeoxyglucose uptake on positron emission tomography, reflecting inflammation, inde...

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Published in:Stroke (1970) 2020-03, Vol.51 (3), p.838-845
Main Authors: Kelly, Peter J., Camps-Renom, Pol, Giannotti, Nicola, Martí-Fàbregas, Joan, McNulty, Jonathan P., Baron, Jean-Claude, Barry, Mary, Coutts, Shelagh B., Cronin, Simon, Delgado-Mederos, Raquel, Dolan, Eamon, Fernández-León, Alejandro, Foley, Shane, Harbison, Joseph, Horgan, Gillian, Kavanagh, Eoin, Marnane, Michael, McCabe, John, McDonnell, Ciaran, Sharma, Vijay K., Williams, David J., O’Connell, Martin, Murphy, Sean
Format: Article
Language:English
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Summary:BACKGROUND AND PURPOSE—In randomized trials of symptomatic carotid endarterectomy, only modest benefit occurred in patients with moderate stenosis and important subgroups experienced no benefit. Carotid plaque F-fluorodeoxyglucose uptake on positron emission tomography, reflecting inflammation, independently predicts recurrent stroke. We investigated if a risk score combining stenosis and plaque F-fluorodeoxyglucose would improve the identification of early recurrent stroke. METHODS—We derived the score in a prospective cohort study of recent (
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.119.027268