Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence

The synthesis and photophysical properties of a new class of α-amino acid bearing a rigid pyrazoloquinazoline chromophore are described. Confromational constraint of the amino acid side-chains resulted in high emission quantum yields, while the demonstration of two-photon-induced fluorescence via ne...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-02, Vol.56 (12), p.1887-1890
Main Authors: Bell, Jonathan D, Harkiss, Alexander H, Nobis, David, Malcolm, Eilidh, Knuhtsen, Astrid, Wellaway, Christopher R, Jamieson, Andrew G, Magennis, Steven W, Sutherland, Andrew
Format: Article
Language:English
Subjects:
Amino acids
Chromophores
Fluorescence
Medical imaging
Near infrared radiation
NMR
Nuclear magnetic resonance
Photons
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Summary:The synthesis and photophysical properties of a new class of α-amino acid bearing a rigid pyrazoloquinazoline chromophore are described. Confromational constraint of the amino acid side-chains resulted in high emission quantum yields, while the demonstration of two-photon-induced fluorescence via near-IR excitation signifies their potential for sensitive bioimaging applications.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc09064a