Molecular Self‐Assembly of Cyclic Dipeptide Derivatives and Their Applications

Cyclic dipeptides (CDPs) are heterocyclic 2,5‐diketopiperazines with exceptional structural rigidity, enzymatic stability, and biological activity, exhibiting a substantial tendency to take part in intermolecular interactions. Strong intermolecular interactions driven by unique hydrogen bonding patt...

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Bibliographic Details
Published in:ChemPlusChem (Weinheim, Germany) Germany), 2017-01, Vol.82 (1), p.88-106
Main Authors: Manchineella, Shivaprasad, Govindaraju, T.
Format: Article
Language:English
Subjects:
biomaterials
bionanotechnology
chiral auxiliaries
cyclic dipeptides
self-assembly
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Summary:Cyclic dipeptides (CDPs) are heterocyclic 2,5‐diketopiperazines with exceptional structural rigidity, enzymatic stability, and biological activity, exhibiting a substantial tendency to take part in intermolecular interactions. Strong intermolecular interactions driven by unique hydrogen bonding patterns render CDPs with a high propensity to undergo molecular self‐assembly. In this Review, the aim is to provide a comprehensive summary of design strategies used to engineer the molecular self‐assembly of CDPs into functional nano‐ and micro‐architectures and molecular gels with potential applications in biomedical and materials engineering fields. Robust synthons: Cyclic dipeptides (CDPs) are 2,5‐diketopiperazines with exceptional structural rigidity, enzymatic stability and biological activity. CDPs are robust platforms for molecular self‐assembly owing to their propensity to engage in intermolecular hydrogen bonding and other noncovalent interactions. Recent advances in engineering functional architectures of CDPs and their prospective applications are discussed.
ISSN:2192-6506
2192-6506
DOI:10.1002/cplu.201600450