Ratiometric detection of amyloid-β aggregation by a dual-emissive tris-heteroleptic ruthenium complex

A dual-emissive tris-heteroleptic ruthenium complex is designed, synthesized and applied for the ratiometric photoluminescent detection of amyloid-β (Aβ) aggregation in both steady and transient states. The Aβ aggregation is supported by transmission electron microscopy and confocal laser scanning m...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-02, Vol.56 (14), p.287-29
Main Authors: Shao, Jiang-Yang, Wu, Si-Hai, Ma, Junjie, Gong, Zhong-Liang, Sun, Tian-Ge, Jin, Yulong, Yang, Rong, Sun, Bin, Zhong, Yu-Wu
Format: Article
Language:English
Subjects:
Agglomeration
Amyloid beta-Peptides - analysis
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Humans
Mathematical analysis
Microscopes
Microscopy
Molecular docking
Molecular Docking Simulation
Molecular Structure
Photoluminescence
Protein Aggregates
Ruthenium - chemistry
Ruthenium compounds
Scanning microscopy
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Summary:A dual-emissive tris-heteroleptic ruthenium complex is designed, synthesized and applied for the ratiometric photoluminescent detection of amyloid-β (Aβ) aggregation in both steady and transient states. The Aβ aggregation is supported by transmission electron microscopy and confocal laser scanning microscopy analysis. In addition, molecular docking calculations have been performed to gain insights into the interaction mode between the ruthenium complex and Aβ fibrils. A dual-emissive tris-heteroleptic ruthenium complex is reported for the ratiometric photoluminescent detection of amyloid-β aggregation in steady and transient states.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc08909h