Central pathology review of salivary gland adenoid cystic carcinoma

Background To assess the role of a central pathology review in the diagnosis of salivary gland adenoid cystic carcinoma (AdCC). Methods Surgically resected salivary gland tumors diagnosed as AdCC (n = 219) in 15 reference hospitals in Japan were subjected to a retrospective pathological re‐evaluatio...

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Bibliographic Details
Published in:Head & neck 2020-08, Vol.42 (8), p.1721-1727
Main Authors: Ueda, Kaori, Murase, Takayuki, Nagao, Toshitaka, Kusafuka, Kimihide, Urano, Makoto, Yamamoto, Hidetaka, Nakaguro, Masato, Taguchi, Ken‐ichi, Masaki, Ayako, Hirai, Hideaki, Kawakita, Daisuke, Tsukahara, Kiyoaki, Hato, Naohito, Nagao, Toru, Fujimoto, Yasushi, Sakurai, Kazuo, Hanai, Nobuhiro, Kano, Satoshi, Onitsuka, Tetsuro, Okami, Kenji, Nibu, Ken‐ichi, Tada, Yuichiro, Kawata, Ryo, Inagaki, Hiroshi
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenoid
adenoid cystic carcinoma
Adenoma
basal cell adenoma/basal cell adenocarcinoma
Carcinoma
central pathology review
cribriform variant
Diagnosis
Head and neck
Pathology
Radiation therapy
Salivary gland
Tumors
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Summary:Background To assess the role of a central pathology review in the diagnosis of salivary gland adenoid cystic carcinoma (AdCC). Methods Surgically resected salivary gland tumors diagnosed as AdCC (n = 219) in 15 reference hospitals in Japan were subjected to a retrospective pathological re‐evaluation. Results After the review, the AdCC diagnosis was revised in 21/219 cases (9.6%). The six benign tumors (2.7%) comprised five basal cell adenomas and one pleomorphic adenoma, and among these six patients, three received postoperative radiotherapy. The remaining 15 malignant tumors (6.8%) comprised nine basal cell adenocarcinomas and six other carcinomas. All revised basal cell adenoma/adenocarcinoma cases were of rare cribriform variants. Conclusions A significant proportion of AdCC pathology reports were revised after the central pathology review. It should be emphasized that the greatest attention should be paid in differentiating AdCC from cribriform variant basal cell adenoma/adenocarcinoma, which is very rare in salivary gland tumors.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26081