Influx rate constant of 18F-FDG increases in metastatic lymph nodes of non-small cell lung cancer patients

• Published in: European journal of nuclear medicine and molecular imaging 2020-05, Vol.47 (5), p.1198-1208
• Main Authors: Yang, Min, Lin, Zhong, Xu, Zeqing, Li, Dan, Lv, Weize, Yang, Shuai, Liu, Ye, Cao, Ying, Cao, Qingdong, Jin, Hongjun
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; Cardiology; Clinical trials; Dynamic models; Epidermal growth factor receptors; Fluorine isotopes; Imaging; Lung cancer; Lymph nodes; Lymphatic system; Medical imaging; Medicine; Medicine & Public Health; Metastases; Metastasis; Modelling; Mutants; Non-small cell lung carcinoma; Nuclear Medicine; Oncology; Oncology – Chest; Original Article; Orthopedics; Patients; Positron emission; Positron emission tomography; Radiology; Small cell lung carcinoma; Squamous cell carcinoma; Tomography
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-020-04682-5

Purpose Primary tumor (PT) and metastatic lymph node (MLN) status have a great influence on diagnosis and treatment of lung cancer. Our main purpose was to investigate the imaging characteristics of PT or MLN by applying the 18 F-FDG PET dynamic modeling approach for non-small cell lung cancer (NSCLC). Methods Dynamic 18 F-FDG PET scans were performed for 76 lung cancer patients, and 62 NSCLC cases were finally included in this study: 37 with newly diagnosed early and locally advanced lung cancer without distant metastases (group M0) and 25 metastatic lung cancer (group M1). Patlak graphic analysis (K i calculation) based on the dynamic modeling and SUV analysis from conventional static data were performed. Results For PT, both K i PT (0.050 ± 0.005 vs 0.026 ± 0.004 min −1 , p