Association of toll‐like receptor 10 polymorphisms with pediatric pneumococcal meningitis

• Published in: APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2020-04, Vol.128 (4), p.335-342
• Main Authors: Xiang, Qiaoyan, Zhu, Liang, Zheng, Kai, Ding, Yiwei, Chen, Ning, Liu, Gang, He, Qiushui
• Format: Article
• Language: English
• Subjects: Alleles; Asian Continental Ancestry Group - genetics; Bacteriology; Case-Control Studies; Cerebrospinal fluid; Child, Preschool; Children; clinical microbiology; Cytokines; Cytokines - genetics; Female; Gene Frequency - genetics; gene polymorphisms; Genetic Predisposition to Disease - genetics; Genotype; Genotypes; Haplotypes; Haplotypes - genetics; Humans; Immunoassay; immunology; Inflammation; Inflammation - genetics; Interferon; interleukins; Male; Meningitis; Meningitis, Pneumococcal - genetics; Nucleotides; Pediatrics; pneumococcal meningitis; Polymorphism, Single Nucleotide - genetics; prognostic markers; Proteins; Single-nucleotide polymorphism; TLR10; Toll-Like Receptor 10 - genetics; Toll-like receptors; Tumor necrosis factor
• ISSN: 0903-4641; 1600-0463
• DOI: 10.1111/apm.13028

We aimed to investigate whether the gene polymorphisms of TLR10 were associated with risk and severity of pneumococcal meningitis (PM) and serum cytokine levels in children. Three single nucleotide polymorphisms (SNPs) of TLR10 rs4129009 (2676A > G), rs10004195 (1018T > A) and rs11466617 (40735A > G) were studied in 95 laboratory‐confirmed PM pediatric patients and 330 healthy controls by PCR‐based sequencing. Ten serum cytokines were determined by multiplex immunoassay. The frequency of variant haplotype GAG of TLR10 was significantly lower in patients than controls (11.3% vs 33.3%, p 1000 mg/L than those who had CSF protein ≤1000 mg/L (3.50% vs 32.4%, p