Correlation between regional brain volume and olfactory function in very mild amnestic patients

We aimed to determine neural correlates of olfactory detection and identification and analyze associations between cognitive function and olfactory identification or detection in very mild amnestic patients. We recruited 70 patients with chief complaints of memory impairment diagnosed as amnestic mi...

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Bibliographic Details
Published in:Journal of the neurological sciences 2020-04, Vol.411, p.116686-116686, Article 116686
Main Authors: Kashibayashi, Tetsuo, Takahashi, Ryuichi, Fujita, Jun, Kamimura, Naoto, Okutani, Fumino, Kazui, Hiroaki
Format: Article
Language:English
Subjects:
Alzheimer Disease - complications
Alzheimer Disease - diagnostic imaging
Alzheimer's disease
Brain - diagnostic imaging
Cognitive Dysfunction - diagnostic imaging
Gray Matter
Humans
Magnetic Resonance Imaging
Mild cognitive impairment
Neuropsychological Tests
Olfactory detection
Olfactory identification
Voxel-based morphometry
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Summary:We aimed to determine neural correlates of olfactory detection and identification and analyze associations between cognitive function and olfactory identification or detection in very mild amnestic patients. We recruited 70 patients with chief complaints of memory impairment diagnosed as amnestic mild cognitive impairment (MCI) or Alzheimer's disease (AD) with a clinical dementia rating of 0.5. Olfactory detection and identification were assessed using T&T olfactometry. A voxel-wise correlation analysis of gray matter volume and olfactometry scores was performed. We also analyzed correlations between neuropsychological results and olfactometry scores. A significant negative correlation was observed between detection scores and nucleus accumbens and left parahippocampal gyrus volumes and between identification scores and orbitofrontal, right frontal, and right anterior temporal cortex volumes (p 
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2020.116686