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Correlation between regional brain volume and olfactory function in very mild amnestic patients
We aimed to determine neural correlates of olfactory detection and identification and analyze associations between cognitive function and olfactory identification or detection in very mild amnestic patients. We recruited 70 patients with chief complaints of memory impairment diagnosed as amnestic mi...
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| Published in: | Journal of the neurological sciences 2020-04, Vol.411, p.116686-116686, Article 116686 |
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| cites | cdi_FETCH-LOGICAL-c419t-654ab6037b9dae91875277cb9f43f66c7db9392ba9ef16316ec5899d229ab623 |
| container_end_page | 116686 |
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| container_start_page | 116686 |
| container_title | Journal of the neurological sciences |
| container_volume | 411 |
| creator | Kashibayashi, Tetsuo Takahashi, Ryuichi Fujita, Jun Kamimura, Naoto Okutani, Fumino Kazui, Hiroaki |
| description | We aimed to determine neural correlates of olfactory detection and identification and analyze associations between cognitive function and olfactory identification or detection in very mild amnestic patients.
We recruited 70 patients with chief complaints of memory impairment diagnosed as amnestic mild cognitive impairment (MCI) or Alzheimer's disease (AD) with a clinical dementia rating of 0.5. Olfactory detection and identification were assessed using T&T olfactometry. A voxel-wise correlation analysis of gray matter volume and olfactometry scores was performed. We also analyzed correlations between neuropsychological results and olfactometry scores.
A significant negative correlation was observed between detection scores and nucleus accumbens and left parahippocampal gyrus volumes and between identification scores and orbitofrontal, right frontal, and right anterior temporal cortex volumes (p |
| doi_str_mv | 10.1016/j.jns.2020.116686 |
| format | article |
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We recruited 70 patients with chief complaints of memory impairment diagnosed as amnestic mild cognitive impairment (MCI) or Alzheimer's disease (AD) with a clinical dementia rating of 0.5. Olfactory detection and identification were assessed using T&T olfactometry. A voxel-wise correlation analysis of gray matter volume and olfactometry scores was performed. We also analyzed correlations between neuropsychological results and olfactometry scores.
A significant negative correlation was observed between detection scores and nucleus accumbens and left parahippocampal gyrus volumes and between identification scores and orbitofrontal, right frontal, and right anterior temporal cortex volumes (p < .001). No significant correlation existed between detection and cognitive assessment scores. Identification score was significantly correlated with the Alzheimer's Disease Assessment Scale-Cognitive Part word recall score (r = 0.305, p = .01).
Olfactory detection and identification dysfunction were attributable to impairments in different regions in MCI and very early AD; the former was attributed to the olfactory circuit, while the latter to neocortices. The dysfunction of identification of olfactory information was associated with episodic memory in those patients.
•We aimed to determine the regions associated with olfactory detection and perception using VBM.•We found significant association of olfactory detection with the olfactory circuit and that of perception with neocortices in MCI and early AD.•Our findings indicated the presence of a neural substrate for dysfunction on the olfactory tasks in MCI and very early AD.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2020.116686</identifier><identifier>PMID: 31972350</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alzheimer Disease - complications ; Alzheimer Disease - diagnostic imaging ; Alzheimer's disease ; Brain - diagnostic imaging ; Cognitive Dysfunction - diagnostic imaging ; Gray Matter ; Humans ; Magnetic Resonance Imaging ; Mild cognitive impairment ; Neuropsychological Tests ; Olfactory detection ; Olfactory identification ; Voxel-based morphometry</subject><ispartof>Journal of the neurological sciences, 2020-04, Vol.411, p.116686-116686, Article 116686</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-654ab6037b9dae91875277cb9f43f66c7db9392ba9ef16316ec5899d229ab623</citedby><cites>FETCH-LOGICAL-c419t-654ab6037b9dae91875277cb9f43f66c7db9392ba9ef16316ec5899d229ab623</cites><orcidid>0000-0002-0046-4628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31972350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kashibayashi, Tetsuo</creatorcontrib><creatorcontrib>Takahashi, Ryuichi</creatorcontrib><creatorcontrib>Fujita, Jun</creatorcontrib><creatorcontrib>Kamimura, Naoto</creatorcontrib><creatorcontrib>Okutani, Fumino</creatorcontrib><creatorcontrib>Kazui, Hiroaki</creatorcontrib><title>Correlation between regional brain volume and olfactory function in very mild amnestic patients</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>We aimed to determine neural correlates of olfactory detection and identification and analyze associations between cognitive function and olfactory identification or detection in very mild amnestic patients.
We recruited 70 patients with chief complaints of memory impairment diagnosed as amnestic mild cognitive impairment (MCI) or Alzheimer's disease (AD) with a clinical dementia rating of 0.5. Olfactory detection and identification were assessed using T&T olfactometry. A voxel-wise correlation analysis of gray matter volume and olfactometry scores was performed. We also analyzed correlations between neuropsychological results and olfactometry scores.
A significant negative correlation was observed between detection scores and nucleus accumbens and left parahippocampal gyrus volumes and between identification scores and orbitofrontal, right frontal, and right anterior temporal cortex volumes (p < .001). No significant correlation existed between detection and cognitive assessment scores. Identification score was significantly correlated with the Alzheimer's Disease Assessment Scale-Cognitive Part word recall score (r = 0.305, p = .01).
Olfactory detection and identification dysfunction were attributable to impairments in different regions in MCI and very early AD; the former was attributed to the olfactory circuit, while the latter to neocortices. The dysfunction of identification of olfactory information was associated with episodic memory in those patients.
•We aimed to determine the regions associated with olfactory detection and perception using VBM.•We found significant association of olfactory detection with the olfactory circuit and that of perception with neocortices in MCI and early AD.•Our findings indicated the presence of a neural substrate for dysfunction on the olfactory tasks in MCI and very early AD.</description><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer's disease</subject><subject>Brain - diagnostic imaging</subject><subject>Cognitive Dysfunction - diagnostic imaging</subject><subject>Gray Matter</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Mild cognitive impairment</subject><subject>Neuropsychological Tests</subject><subject>Olfactory detection</subject><subject>Olfactory identification</subject><subject>Voxel-based morphometry</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAQhC0EoqXwA7ggH7mk-JE4sTihipdUiUsP3CzH2SBXiV3spKj_HpcWjpxWu_pmtDMIXVMyp4SKu_V87eKcEZZ2KkQlTtCUVmWVFVXFT9GUEMaygpL3CbqIcU0IEVUlz9GEU1kyXpApUgsfAnR6sN7hGoYvAIcDfKRVd7gO2jq89d3YA9auwb5rtRl82OF2dOZHtAcgHXrbNVj3DuJgDd4kR3BDvERnre4iXB3nDK2eHleLl2z59vy6eFhmJqdyyESR61oQXtay0SBTiIKVpallm_NWCFM2teSS1VpCSwWnAkxRSdkwJpOO8Rm6Pdhugv8c0wuqt9FA12kHfoyK8TxnZU7yPUoPqAk-xgCt2gTb67BTlKh9rWqtUq1qX6s61Jo0N0f7se6h-VP89piA-wMAKePWQlDRpPwGGhvADKrx9h_7b6_wiWU</recordid><startdate>20200415</startdate><enddate>20200415</enddate><creator>Kashibayashi, Tetsuo</creator><creator>Takahashi, Ryuichi</creator><creator>Fujita, Jun</creator><creator>Kamimura, Naoto</creator><creator>Okutani, Fumino</creator><creator>Kazui, Hiroaki</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0046-4628</orcidid></search><sort><creationdate>20200415</creationdate><title>Correlation between regional brain volume and olfactory function in very mild amnestic patients</title><author>Kashibayashi, Tetsuo ; Takahashi, Ryuichi ; Fujita, Jun ; Kamimura, Naoto ; Okutani, Fumino ; Kazui, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-654ab6037b9dae91875277cb9f43f66c7db9392ba9ef16316ec5899d229ab623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer's disease</topic><topic>Brain - diagnostic imaging</topic><topic>Cognitive Dysfunction - diagnostic imaging</topic><topic>Gray Matter</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Mild cognitive impairment</topic><topic>Neuropsychological Tests</topic><topic>Olfactory detection</topic><topic>Olfactory identification</topic><topic>Voxel-based morphometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kashibayashi, Tetsuo</creatorcontrib><creatorcontrib>Takahashi, Ryuichi</creatorcontrib><creatorcontrib>Fujita, Jun</creatorcontrib><creatorcontrib>Kamimura, Naoto</creatorcontrib><creatorcontrib>Okutani, Fumino</creatorcontrib><creatorcontrib>Kazui, Hiroaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kashibayashi, Tetsuo</au><au>Takahashi, Ryuichi</au><au>Fujita, Jun</au><au>Kamimura, Naoto</au><au>Okutani, Fumino</au><au>Kazui, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between regional brain volume and olfactory function in very mild amnestic patients</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2020-04-15</date><risdate>2020</risdate><volume>411</volume><spage>116686</spage><epage>116686</epage><pages>116686-116686</pages><artnum>116686</artnum><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>We aimed to determine neural correlates of olfactory detection and identification and analyze associations between cognitive function and olfactory identification or detection in very mild amnestic patients.
We recruited 70 patients with chief complaints of memory impairment diagnosed as amnestic mild cognitive impairment (MCI) or Alzheimer's disease (AD) with a clinical dementia rating of 0.5. Olfactory detection and identification were assessed using T&T olfactometry. A voxel-wise correlation analysis of gray matter volume and olfactometry scores was performed. We also analyzed correlations between neuropsychological results and olfactometry scores.
A significant negative correlation was observed between detection scores and nucleus accumbens and left parahippocampal gyrus volumes and between identification scores and orbitofrontal, right frontal, and right anterior temporal cortex volumes (p < .001). No significant correlation existed between detection and cognitive assessment scores. Identification score was significantly correlated with the Alzheimer's Disease Assessment Scale-Cognitive Part word recall score (r = 0.305, p = .01).
Olfactory detection and identification dysfunction were attributable to impairments in different regions in MCI and very early AD; the former was attributed to the olfactory circuit, while the latter to neocortices. The dysfunction of identification of olfactory information was associated with episodic memory in those patients.
•We aimed to determine the regions associated with olfactory detection and perception using VBM.•We found significant association of olfactory detection with the olfactory circuit and that of perception with neocortices in MCI and early AD.•Our findings indicated the presence of a neural substrate for dysfunction on the olfactory tasks in MCI and very early AD.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31972350</pmid><doi>10.1016/j.jns.2020.116686</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0046-4628</orcidid></addata></record> |
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| subjects | Alzheimer Disease - complications Alzheimer Disease - diagnostic imaging Alzheimer's disease Brain - diagnostic imaging Cognitive Dysfunction - diagnostic imaging Gray Matter Humans Magnetic Resonance Imaging Mild cognitive impairment Neuropsychological Tests Olfactory detection Olfactory identification Voxel-based morphometry |
| title | Correlation between regional brain volume and olfactory function in very mild amnestic patients |
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