Prevalence and Effect of Intestinal Infections Detected by a PCR-Based Stool Test in Patients with Inflammatory Bowel Disease

Background The advent of PCR-based stool testing has identified a greatly increased number of infectious agents in IBD, but their clinical significance is unknown. Aims To determine the infectious agent prevalence and the clinical significance of these infectious agents in IBD patients. Methods This...

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Bibliographic Details
Published in:Digestive diseases and sciences 2020-11, Vol.65 (11), p.3287-3296
Main Authors: Limsrivilai, Julajak, Saleh, Zachary M., Johnson, Laura A., Stidham, Ryan W., Waljee, Akbar K., Govani, Shail M., Gutermuth, Brian, Brown, Alexandra M., Briggs, Emily, Rao, Krishna, Higgins, Peter D. R.
Format: Article
Language:English
Subjects:
Adult
Bacterial Infections - epidemiology
Bacterial Infections - microbiology
Biochemistry
Care and treatment
Case-Control Studies
Comparative analysis
Cross-Sectional Studies
Feces - microbiology
Female
Gastroenterology
Health aspects
Hepatology
Humans
Immunosuppressive agents
Immunotherapy
Inflammatory Bowel Diseases - epidemiology
Inflammatory Bowel Diseases - microbiology
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Michigan - epidemiology
Middle Aged
Oncology
Original Article
Polymerase Chain Reaction
Prevalence
Prevalence studies (Epidemiology)
Prospective Studies
Transplant Surgery
Ulcerative colitis
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Summary:Background The advent of PCR-based stool testing has identified a greatly increased number of infectious agents in IBD, but their clinical significance is unknown. Aims To determine the infectious agent prevalence and the clinical significance of these infectious agents in IBD patients. Methods This cross-sectional study compared the prevalence of GI infections among IBD patients with active and quiescent disease versus healthy controls. Among actively inflamed patients, we compared clinical characteristics, medication use, and disease course between those with positive and negative tests. Results Three hundred and thirty-three IBD patients and 52 healthy volunteers were included. The IBD group was divided into active Crohn’s disease (CD, n  = 113), inactive CD ( n  = 53), active ulcerative colitis (UC, n  = 128), and inactive UC ( n  = 39). A significantly higher percentage of actively inflamed patients had positive stool tests (31.1%) compared to those with quiescent disease (7.6%, P  = 
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-020-06071-2