Emerging nanomedicine-based strategies for preventing metastasis of pancreatic cancer

Pancreatic cancer is highly metastatic with very short survival and increasing mortality rates. Recent advances in therapeutic regimes and other adjuvant therapies improved slightly overall survival of pancreatic cancer, but fighting metastasis has been challenging and is necessary for achieving cur...

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Bibliographic Details
Published in:Journal of controlled release 2020-04, Vol.320, p.105-111
Main Authors: Li, Yong-Jiang, Wu, Jun-Yong, Wang, Jie-Min, Xiang, Da-Xiong
Format: Article
Language:English
Subjects:
Cancer stem cells
Circulating tumor cells
Exosomes
Metastasis
Nanomedicine
Nanotechnology
Pancreatic cancer
Tumor microenvironment
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Summary:Pancreatic cancer is highly metastatic with very short survival and increasing mortality rates. Recent advances in therapeutic regimes and other adjuvant therapies improved slightly overall survival of pancreatic cancer, but fighting metastasis has been challenging and is necessary for achieving cure. Nanomedicine, not limited to drug delivery, offers opportunities for targeting cancer metastasis. Research regarding the prevention of metastasis of this malignancy is highly demanded. Herein, we focus on advances of nanomedicine-based strategies for targeting different stages of metastasis, including cancer stem cells, tumor microenvironment, circulating tumor cells and tumor exosomes. A greater emphasis on targeting metastasis of pancreatic cancer using nanomedicine-based strategies provides avenues for improving pancreatic cancer treatment outcomes in the future. [Display omitted] •Pancreatic cancer is highly metastatic, but nanomedicine offered opportunities for fighting against metastasis.•Targeting cancer stem cells in the first place is important for preventing metastasis spread.•Remodeling the tumor microenvironment is preferable for intratumoral delivery of chemotherapeutics.•Targeting circulating tumor cells is a feasible strategy for preventing metastatic colony formation•Targeting oncogenic exosomes using specific markers may also to prevent metastasis of PDAC
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2020.01.041