Urinary neutrophil gelatinase-associated lipocalin as an early biomarker for acute kidney injury in dogs

Neutrophil gelatinase-associated lipocalin (NGAL) is used as an early biomarker of renal injury in people. In dogs, increases in urinary NGAL (uNGAL) precede increases in serum creatinine (sCr) in experimental and clinical evaluations of acute kidney injury (AKI) and chronic kidney disease. This stu...

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Bibliographic Details
Published in:The veterinary journal (1997) 2020-01, Vol.255, p.105423-105423, Article 105423
Main Authors: Scheemaeker, S., Meyer, E., Schoeman, J.P., Defauw, P., Duchateau, L., Daminet, S.
Format: Article
Language:English
Subjects:
Acute kidney injury
Dog
NGAL
Renal biomarker
Snake envenomation
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Summary:Neutrophil gelatinase-associated lipocalin (NGAL) is used as an early biomarker of renal injury in people. In dogs, increases in urinary NGAL (uNGAL) precede increases in serum creatinine (sCr) in experimental and clinical evaluations of acute kidney injury (AKI) and chronic kidney disease. This study compared uNGAL in two subsets of dogs with AKI and their respective controls. One set included dogs with snake-envenomation at risk for or presenting with International Renal Interest Society (IRIS) grade I AKI; the other group included dogs with AKI, where renal injury was the result of various causes, and IRIS grade was ≥II. Additionally, this study evaluated haemoglobin (Hb) interference during NGAL analysis in Hb spiked urine and plasma from healthy dogs. In both AKI groups, uNGAL was significantly higher than in matched healthy control dogs (P
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2019.105423