Contemporary Outcomes for Infants with Necrotizing Enterocolitis—A Systematic Review

To develop an accurate understanding of outcomes for necrotizing enterocolitis (NEC) to inform parental counseling, clinical care, and research agendas. A systematic review of recent (January 2010-January 2018) large cohort studies reporting outcomes of infants who developed NEC. Only studies report...

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Bibliographic Details
Published in:The Journal of pediatrics 2020-05, Vol.220, p.86-92.e3
Main Authors: Jones, Ian H., Hall, Nigel J.
Format: Article
Language:English
Subjects:
intestinal failure
mortality
necrotizing enterocolitis
neurodevelopmental delay
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Summary:To develop an accurate understanding of outcomes for necrotizing enterocolitis (NEC) to inform parental counseling, clinical care, and research agendas. A systematic review of recent (January 2010-January 2018) large cohort studies reporting outcomes of infants who developed NEC. Only studies reporting national, regional, or multicenter outcomes of NEC in high income countries were included. Outcomes assessed were mortality, neurodevelopmental outcome, and intestinal failure. Meta-analyses were used to generate summary statistics for these outcomes. Of 1375 abstracts, 38 articles were included. Overall mortality was 23.5% in all neonates with confirmed NEC (Bell stage 2a+) (95% CI 18.5%-28.8%), 34.5% (30.1%-39.2%) for neonates that underwent surgery for NEC, 40.5% (37.2%-43.8%) for extremely low birthweight infants (
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2019.11.011