High-density lipoprotein-mediated cardioprotection in heart failure

The prevalence of heart failure (HF), including reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF), has increased significantly worldwide. However, the prognosis and treatment of HF are still not good. Recent studies have demonstrated that high-density lipoprotein (HDL) plays...

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Bibliographic Details
Published in:Heart failure reviews 2021-07, Vol.26 (4), p.767-780
Main Authors: Jackson, Ampadu O., Meng, Jun, Tang, Huifang, Yin, Kai
Format: Article
Language:English
Subjects:
Cardiology
Cardiomyocytes
Congestive heart failure
Contraction
Ejection fraction
Endothelial cells
Energy balance
Excitation-contraction coupling
Heart failure
High density lipoprotein
Homeostasis
Medicine
Medicine & Public Health
Microvasculature
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Summary:The prevalence of heart failure (HF), including reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF), has increased significantly worldwide. However, the prognosis and treatment of HF are still not good. Recent studies have demonstrated that high-density lipoprotein (HDL) plays an important role in cardiac repair during HF. The exact role and mechanism of HDL in the regulation of HF remain unexplained. Here, we discuss recent findings regarding HDL in the progression of HF, such as the regulation of excitation-contraction coupling, energy homeostasis, inflammation, neurohormone activation, and microvascular dysfunction. The effects of HDL on the regulation of cardiac-related cells, such as endothelial cells (ECs), cardiomyocytes (CMs), and on cardiac resident immune cell dysfunction in HF are also explained. An in-depth understanding of HDL function in the heart may provide new strategies for the prevention and treatment of HF.
ISSN:1382-4147
1573-7322
DOI:10.1007/s10741-020-09916-0