Nutraceutical Augmentation Strategies for Depression: A Narrative Review

Depression is one of the most commonly diagnosed psychiatric disorders, but antidepressant pharmacotherapy often fails to achieve remission, leading health care professionals and researchers to consider various augmentation strategies to improve clinical outcomes. To assess the safety, tolerability,...

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Bibliographic Details
Published in:Journal of Osteopathic Medicine (Online) 2020-02, Vol.120 (2), p.100-106
Main Author: Gregory Lande, R.
Format: Article
Language:English
Subjects:
Antidepressants
Clinical medicine
Collaboration
depression
Dietary supplements
Drug therapy
Fatty acids
Functional foods & nutraceuticals
Medical personnel
Mental depression
Mental disorders
nutraceuticals
Omega-3 fatty acids
Patients
psychiatric disorders
Remission (Medicine)
Systematic review
Vitamin B
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Summary:Depression is one of the most commonly diagnosed psychiatric disorders, but antidepressant pharmacotherapy often fails to achieve remission, leading health care professionals and researchers to consider various augmentation strategies to improve clinical outcomes. To assess the safety, tolerability, and efficacy of nutraceutical augmentation for depression. Nutraceutical-focused systematic reviews and clinical practice guidelines identified the more commonly studied augmentation strategies for depression. S-adenosylmethionine, l-methylfolate, omega-3 fatty acids, and hydroxyvitamin D have sufficient scientific evidence to support their clinical consideration in the stepped care approach to the management of depression. Clinical remission is the goal in the management of depression, and nutraceuticals may be part of an overall treatment approach to achieve that outcome.
ISSN:2702-3648
2702-3648
1945-1997
DOI:10.7556/jaoa.2020.019