Sentinel node total tumour load as a predictive factor for non-sentinel node status in early breast cancer patients – The porttle study

OSNA is a molecular assay for the detection of sentinel node metastasis. TTL emerged as a concept that seems to accurately predict the status of the NSN. Authors tried to confirm this motion. This is a retrospective and multicentric study that analyzed 2164 patients, 579 of whom had positive SN and...

Full description

Saved in:
Bibliographic Details
Published in:Surgical oncology 2020-03, Vol.32, p.108-114
Main Authors: Fougo, José Luis, Amendoeira, Isabel, Brito, Maria José, Correia, Ana Paula, Gonçalves, Ana, Honavar, Mrinalini, Machado, Arnaldo, Magalhães, André, Marta, Susana, Nogueira, Madalena, Peleteiro, Bárbara, Pontes, Patrícia
Format: Article
Language:English
Subjects:
Biopsy
Breast cancer
Dissection
Lymphatic system
Metastases
Metastasis
Nodes
Non-sentinel node
OSNA
Patients
Prediction
Regression analysis
Regression models
Sentinel node
Studies
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OSNA is a molecular assay for the detection of sentinel node metastasis. TTL emerged as a concept that seems to accurately predict the status of the NSN. Authors tried to confirm this motion. This is a retrospective and multicentric study that analyzed 2164 patients, 579 of whom had positive SN and completion AD. Logistic regression models were performed in order to identify a suitable cutoff to identify patients who benefit from AD. Univariate and multivariate regression analysis showed a relationship between TTL>30000 and the presence of NSN metastasis (OR 2.84, CI 1.99–4.08, p 
ISSN:0960-7404
1879-3320
DOI:10.1016/j.suronc.2019.11.008