The influence of a lipid reservoir on the tear film formation

Abstract We present a mathematical model to study the influence of a lipid reservoir, seen experimentally, at the lid margin on the formation and relaxation of the tear film during a partial blink. Applying the lubrication limit, we derive two coupled non-linear partial differential equations charac...

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Bibliographic Details
Published in:Mathematical medicine and biology 2020-09, Vol.37 (3), p.363-388
Main Authors: Maki, Kara L, Braun, Richard J, Barron, Gregory A
Format: Article
Language:English
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Summary:Abstract We present a mathematical model to study the influence of a lipid reservoir, seen experimentally, at the lid margin on the formation and relaxation of the tear film during a partial blink. Applying the lubrication limit, we derive two coupled non-linear partial differential equations characterizing the evolution of the aqueous tear fluid and the covering insoluble lipid concentration. Departing from prior works, we explore a new set of boundary conditions (BCs) enforcing hypothesized lipid concentration dynamics at the lid margins. Using both numerical and analytical approaches, we find that the lipid-focused BCs strongly impact tear film formation and thinning rates. Specifically, during the upstroke of the eyelid, we find specifying the lipid concentration at the lid margin accelerates thinning. Parameter regimes that cause tear film formation success or failure are identified. More importantly, this work expands our understanding of the consequences of lipid dynamics near the lid margins for tear film formation.
ISSN:1477-8599
1477-8602
DOI:10.1093/imammb/dqz018