Adjunctive effect of systemic antimicrobials in periodontitis therapy: A systematic review and meta‐analysis

Aim To answer the following PICOS questions: in patients with periodontitis, which is the efficacy of adjunctive systemic antimicrobials, in comparison with subgingival debridement plus a placebo, in terms of probing pocket depth (PPD) reduction, in randomized clinical trials with at least 6 months...

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Published in:Journal of clinical periodontology 2020-07, Vol.47 (S22), p.257-281
Main Authors: Teughels, Wim, Feres, Magda, Oud, Valerie, Martín, Conchita, Matesanz, Paula, Herrera, David
Format: Article
Language:English
Subjects:
Amoxicillin
Amoxicillin - therapeutic use
Anti-Bacterial Agents - therapeutic use
Anti-Infective Agents - therapeutic use
Antimicrobial agents
Azithromycin
Clinical trials
Dental Scaling
Dentistry
Gum disease
Humans
Meta-analysis
Metronidazole
Metronidazole - therapeutic use
Periodontitis
Periodontitis - drug therapy
Root Planing
scaling and root planing
Statistical analysis
systematic review
systemic antimicrobials
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Summary:Aim To answer the following PICOS questions: in patients with periodontitis, which is the efficacy of adjunctive systemic antimicrobials, in comparison with subgingival debridement plus a placebo, in terms of probing pocket depth (PPD) reduction, in randomized clinical trials with at least 6 months of follow‐up? Material and Methods A systematic search was conducted: 34 articles (28 studies) were included. Data on clinical outcome variables changes were pooled and analysed using weighted mean differences (WMDs), 95% confidence intervals (CI) and prediction intervals (PIs), in case of significant heterogeneity. Results For PPD, statistically significant benefits (p 
ISSN:0303-6979
1600-051X
DOI:10.1111/jcpe.13264