Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira

Abstract Mansonella ozzardi and Mansonella perstans infections both cause mansonellosis but are usually treated differently. Using a real-time polymerase chain reaction assay and deep sequencing, we reveal the presence of mansonellosis coinfections that were undetectable by standard diagnostic metho...

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Bibliographic Details
Published in:Clinical infectious diseases 2020-11, Vol.71 (8), p.1990-1993
Main Authors: Crainey, James Lee, Costa, Carlos Henrique Aguiar, de Oliveira Leles, Lorena Ferreira, Ribeiro da Silva, Túllio Romão, de Aquino Narzetti, Luiz Henrique, Serra dos Santos, Yago Vinícius, Costa Conteville, Liliane, Costa Pessoa, Felipe Arley, Carvajal Cortés, José Joaquin, Vicente, Ana Carolina Paulo, Rubio Muñoz, José Miguel, Bessa Luz, Sérgio Luiz
Format: Article
Language:English
Subjects:
Animals
Brazil - epidemiology
Coinfection - diagnosis
Coinfection - epidemiology
High-Throughput Nucleotide Sequencing
Humans
Mansonella
Mansonelliasis
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Summary:Abstract Mansonella ozzardi and Mansonella perstans infections both cause mansonellosis but are usually treated differently. Using a real-time polymerase chain reaction assay and deep sequencing, we reveal the presence of mansonellosis coinfections that were undetectable by standard diagnostic methods. Our results confirm mansonellosis coinfections and have important implications for the disease’s treatment and diagnosis.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciaa082