LncRNA-LUNAR1 Levels Are Closely Related to Coronary Collaterals in Patients with Chronic Total Coronary Occlusion

• Published in: Journal of cardiovascular translational research 2020-04, Vol.13 (2), p.171-180
• Main Authors: Lu, Wenbin, Sheng, Zulong, Zhang, Ziwei, Ma, Genshan, Chen, Lijuan, Huang, Jian, Ding, Jiandong, Dai, Qiming
• Format: Article
• Language: English
• Subjects: Biomedical Engineering and Bioengineering; Biomedicine; Cardiology; Human Genetics; Medicine; Medicine & Public Health; Original Article
• ISSN: 1937-5387; 1937-5395
• DOI: 10.1007/s12265-019-09917-x

Coronary collaterals can effectively improve myocardial blood supply to the area of CTO (chronic total coronary occlusion) and can, thus, reduce infarct size. LUNAR1(leukemia-induced noncoding activator RNA-1) is a specific LncRNA regulated by Notch signaling that not only can enhance the expression of IGFR-1 but also can promote angiogenesis and cell survival. Here, we investigated the relationship between LncRNA-LUNAR1 levels in peripheral plasma and the formation of coronary collaterals. In total, 172 patients with CTO were enrolled and followed up for 12 months. Coronary collaterals were scored according to the Rentrop scoring system. Preclinical tests of tube formation were used to address the mechanisms behind the association between LncRNA-LUNAR1 and development of collaterals. Clinical data and inflammatory factors, including comorbidity, CD14 ++ CD16 − monocytes, and CCL2 (chemokine motif ligand 2), were compared and analyzed. Real-time PCR was used to detect the expression of LncRNA-LUNAR1 in peripheral blood plasma. The Rentrop score was positively correlated with LncRNA-LUNAR1 levels in patients with CTO ( R  = 0.47, p