The Association between Serum Retinol-Binding Protein 4 Levels and Cardiovascular Events in Patients with Chronic Kidney Disease

• Published in: Laboratory medicine 2020-09, Vol.51 (5), p.491-497
• Main Authors: Su, Yuhao, Huang, Ying, Jiang, Ying, Zhu, Meilan
• Format: Article
• Language: English
• Subjects: Aged; Analysis; Cardiac patients; Cardiovascular Diseases - blood; Cardiovascular Diseases - etiology; Cardiovascular Diseases - mortality; Care and treatment; China - epidemiology; Chronic kidney failure; Female; Health aspects; Humans; Kidney diseases; Male; Medical prognosis; Middle Aged; Mortality; Proportional Hazards Models; Prospective Studies; Protein binding; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - complications; Retinoids; Retinol-Binding Proteins, Plasma - metabolism; Type 2 diabetes
• ISSN: 0007-5027; 1943-7730
• DOI: 10.1093/labmed/lmz104

Abstract Objective The study aimed to assess whether serum retinol-binding protein 4 (RBP4) is associated with a risk of cardiovascular (CV) events in chronic kidney disease (CKD) patients. Methods One hundred sixty-nine patients with CKD were followed for a mean of 36 months (range, 5–39 months). Serum RBP4 and other laboratory indicators were measured at baseline. The relationship between RBP4 and the risk of CV events was evaluated by using Cox regression analysis. Results Patients with higher serum RBP4 levels had a higher rate of CV events and a higher mortality in a univariate analysis (P 33.86 mg/L) had a higher rate of CV events than did patients with RBP4 at or below the median value (≤33.86 mg/L; P