Loading…
The Association between Serum Retinol-Binding Protein 4 Levels and Cardiovascular Events in Patients with Chronic Kidney Disease
Abstract Objective The study aimed to assess whether serum retinol-binding protein 4 (RBP4) is associated with a risk of cardiovascular (CV) events in chronic kidney disease (CKD) patients. Methods One hundred sixty-nine patients with CKD were followed for a mean of 36 months (range, 5–39 months). S...
Saved in:
| Published in: | Laboratory medicine 2020-09, Vol.51 (5), p.491-497 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c460t-5a1e07994122adbbb4fcdd8e108c57dd195bbb84ff871cd2f13fa742042b5a003 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c460t-5a1e07994122adbbb4fcdd8e108c57dd195bbb84ff871cd2f13fa742042b5a003 |
| container_end_page | 497 |
| container_issue | 5 |
| container_start_page | 491 |
| container_title | Laboratory medicine |
| container_volume | 51 |
| creator | Su, Yuhao Huang, Ying Jiang, Ying Zhu, Meilan |
| description | Abstract
Objective
The study aimed to assess whether serum retinol-binding protein 4 (RBP4) is associated with a risk of cardiovascular (CV) events in chronic kidney disease (CKD) patients.
Methods
One hundred sixty-nine patients with CKD were followed for a mean of 36 months (range, 5–39 months). Serum RBP4 and other laboratory indicators were measured at baseline. The relationship between RBP4 and the risk of CV events was evaluated by using Cox regression analysis.
Results
Patients with higher serum RBP4 levels had a higher rate of CV events and a higher mortality in a univariate analysis (P 33.86 mg/L) had a higher rate of CV events than did patients with RBP4 at or below the median value (≤33.86 mg/L; P |
| doi_str_mv | 10.1093/labmed/lmz104 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2348803143</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A697614174</galeid><oup_id>10.1093/labmed/lmz104</oup_id><sourcerecordid>A697614174</sourcerecordid><originalsourceid>FETCH-LOGICAL-c460t-5a1e07994122adbbb4fcdd8e108c57dd195bbb84ff871cd2f13fa742042b5a003</originalsourceid><addsrcrecordid>eNqFkc1v1DAQxS1ERZfCkSuyxIVLWn8ljo_LUj7UlaignC3HnnRdJfZiJ1uVE386brdVBUJCPozn6TdPM3oIvaLkmBLFTwbTjeBOhvEnJeIJWlAleCUlJ0_RghAiq5oweYie53xVWqEa9gwdcqqU4lwt0K-LDeBlztF6M_kYcAfTNUDA3yDNI_4Kkw9xqN754Hy4xOcpTuADFngNOxgyNsHhlUnOx53Jdh5Mwqc7CFPGhTovlnf_az9t8GqTYvAWn3kX4Aa_9xlMhhfooDdDhpf39Qh9_3B6sfpUrb98_LxarisrGjJVtaFApFKCMmZc13Wit861QElra-kcVXURW9H3raTWsZ7y3kjBiGBdbQjhR-jt3neb4o8Z8qRHny0MgwkQ56wZF21LOBW8oG_-Qq_inELZTjMhuWxqWdNH6tIMoH3o45SMvTXVy0bJhgoqRaGO_0GV52D0NgbofdH_GKj2AzbFnBP0epv8aNKNpkTfJq73iet94oV_fb_sfCc_0A8RPx4e5-1_vH4DalW18A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473765751</pqid></control><display><type>article</type><title>The Association between Serum Retinol-Binding Protein 4 Levels and Cardiovascular Events in Patients with Chronic Kidney Disease</title><source>Oxford Journals Online</source><creator>Su, Yuhao ; Huang, Ying ; Jiang, Ying ; Zhu, Meilan</creator><creatorcontrib>Su, Yuhao ; Huang, Ying ; Jiang, Ying ; Zhu, Meilan</creatorcontrib><description>Abstract
Objective
The study aimed to assess whether serum retinol-binding protein 4 (RBP4) is associated with a risk of cardiovascular (CV) events in chronic kidney disease (CKD) patients.
Methods
One hundred sixty-nine patients with CKD were followed for a mean of 36 months (range, 5–39 months). Serum RBP4 and other laboratory indicators were measured at baseline. The relationship between RBP4 and the risk of CV events was evaluated by using Cox regression analysis.
Results
Patients with higher serum RBP4 levels had a higher rate of CV events and a higher mortality in a univariate analysis (P < 0.001). The multivariate Cox proportional hazard analysis revealed that RBP4 (hazard ratio, 2.259; 95% confidence interval, 2.067–5.489; P = 0.002) is an independent prognostic factor for CV events in patients with CKD. Kaplan-Meier analysis demonstrated that patients with RBP4 above the median value (>33.86 mg/L) had a higher rate of CV events than did patients with RBP4 at or below the median value (≤33.86 mg/L; P < 0.001).
Conclusion
RBP4 levels are associated with CV events in patients with CKD. Elevated serum RBP4 levels may indicate an increased risk of CV complications in CKD patients.</description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1093/labmed/lmz104</identifier><identifier>PMID: 31999339</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aged ; Analysis ; Cardiac patients ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Care and treatment ; China - epidemiology ; Chronic kidney failure ; Female ; Health aspects ; Humans ; Kidney diseases ; Male ; Medical prognosis ; Middle Aged ; Mortality ; Proportional Hazards Models ; Prospective Studies ; Protein binding ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - complications ; Retinoids ; Retinol-Binding Proteins, Plasma - metabolism ; Type 2 diabetes</subject><ispartof>Laboratory medicine, 2020-09, Vol.51 (5), p.491-497</ispartof><rights>Crown copyright 2020. 2020</rights><rights>Crown copyright 2020.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-5a1e07994122adbbb4fcdd8e108c57dd195bbb84ff871cd2f13fa742042b5a003</citedby><cites>FETCH-LOGICAL-c460t-5a1e07994122adbbb4fcdd8e108c57dd195bbb84ff871cd2f13fa742042b5a003</cites><orcidid>0000-0002-4501-5447</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31999339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Yuhao</creatorcontrib><creatorcontrib>Huang, Ying</creatorcontrib><creatorcontrib>Jiang, Ying</creatorcontrib><creatorcontrib>Zhu, Meilan</creatorcontrib><title>The Association between Serum Retinol-Binding Protein 4 Levels and Cardiovascular Events in Patients with Chronic Kidney Disease</title><title>Laboratory medicine</title><addtitle>Lab Med</addtitle><description>Abstract
Objective
The study aimed to assess whether serum retinol-binding protein 4 (RBP4) is associated with a risk of cardiovascular (CV) events in chronic kidney disease (CKD) patients.
Methods
One hundred sixty-nine patients with CKD were followed for a mean of 36 months (range, 5–39 months). Serum RBP4 and other laboratory indicators were measured at baseline. The relationship between RBP4 and the risk of CV events was evaluated by using Cox regression analysis.
Results
Patients with higher serum RBP4 levels had a higher rate of CV events and a higher mortality in a univariate analysis (P < 0.001). The multivariate Cox proportional hazard analysis revealed that RBP4 (hazard ratio, 2.259; 95% confidence interval, 2.067–5.489; P = 0.002) is an independent prognostic factor for CV events in patients with CKD. Kaplan-Meier analysis demonstrated that patients with RBP4 above the median value (>33.86 mg/L) had a higher rate of CV events than did patients with RBP4 at or below the median value (≤33.86 mg/L; P < 0.001).
Conclusion
RBP4 levels are associated with CV events in patients with CKD. Elevated serum RBP4 levels may indicate an increased risk of CV complications in CKD patients.</description><subject>Aged</subject><subject>Analysis</subject><subject>Cardiac patients</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Care and treatment</subject><subject>China - epidemiology</subject><subject>Chronic kidney failure</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Protein binding</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Retinoids</subject><subject>Retinol-Binding Proteins, Plasma - metabolism</subject><subject>Type 2 diabetes</subject><issn>0007-5027</issn><issn>1943-7730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkc1v1DAQxS1ERZfCkSuyxIVLWn8ljo_LUj7UlaignC3HnnRdJfZiJ1uVE386brdVBUJCPozn6TdPM3oIvaLkmBLFTwbTjeBOhvEnJeIJWlAleCUlJ0_RghAiq5oweYie53xVWqEa9gwdcqqU4lwt0K-LDeBlztF6M_kYcAfTNUDA3yDNI_4Kkw9xqN754Hy4xOcpTuADFngNOxgyNsHhlUnOx53Jdh5Mwqc7CFPGhTovlnf_az9t8GqTYvAWn3kX4Aa_9xlMhhfooDdDhpf39Qh9_3B6sfpUrb98_LxarisrGjJVtaFApFKCMmZc13Wit861QElra-kcVXURW9H3raTWsZ7y3kjBiGBdbQjhR-jt3neb4o8Z8qRHny0MgwkQ56wZF21LOBW8oG_-Qq_inELZTjMhuWxqWdNH6tIMoH3o45SMvTXVy0bJhgoqRaGO_0GV52D0NgbofdH_GKj2AzbFnBP0epv8aNKNpkTfJq73iet94oV_fb_sfCc_0A8RPx4e5-1_vH4DalW18A</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Su, Yuhao</creator><creator>Huang, Ying</creator><creator>Jiang, Ying</creator><creator>Zhu, Meilan</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4501-5447</orcidid></search><sort><creationdate>20200901</creationdate><title>The Association between Serum Retinol-Binding Protein 4 Levels and Cardiovascular Events in Patients with Chronic Kidney Disease</title><author>Su, Yuhao ; Huang, Ying ; Jiang, Ying ; Zhu, Meilan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-5a1e07994122adbbb4fcdd8e108c57dd195bbb84ff871cd2f13fa742042b5a003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>Cardiac patients</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Care and treatment</topic><topic>China - epidemiology</topic><topic>Chronic kidney failure</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Protein binding</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Retinoids</topic><topic>Retinol-Binding Proteins, Plasma - metabolism</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Yuhao</creatorcontrib><creatorcontrib>Huang, Ying</creatorcontrib><creatorcontrib>Jiang, Ying</creatorcontrib><creatorcontrib>Zhu, Meilan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Yuhao</au><au>Huang, Ying</au><au>Jiang, Ying</au><au>Zhu, Meilan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association between Serum Retinol-Binding Protein 4 Levels and Cardiovascular Events in Patients with Chronic Kidney Disease</atitle><jtitle>Laboratory medicine</jtitle><addtitle>Lab Med</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>51</volume><issue>5</issue><spage>491</spage><epage>497</epage><pages>491-497</pages><issn>0007-5027</issn><eissn>1943-7730</eissn><abstract>Abstract
Objective
The study aimed to assess whether serum retinol-binding protein 4 (RBP4) is associated with a risk of cardiovascular (CV) events in chronic kidney disease (CKD) patients.
Methods
One hundred sixty-nine patients with CKD were followed for a mean of 36 months (range, 5–39 months). Serum RBP4 and other laboratory indicators were measured at baseline. The relationship between RBP4 and the risk of CV events was evaluated by using Cox regression analysis.
Results
Patients with higher serum RBP4 levels had a higher rate of CV events and a higher mortality in a univariate analysis (P < 0.001). The multivariate Cox proportional hazard analysis revealed that RBP4 (hazard ratio, 2.259; 95% confidence interval, 2.067–5.489; P = 0.002) is an independent prognostic factor for CV events in patients with CKD. Kaplan-Meier analysis demonstrated that patients with RBP4 above the median value (>33.86 mg/L) had a higher rate of CV events than did patients with RBP4 at or below the median value (≤33.86 mg/L; P < 0.001).
Conclusion
RBP4 levels are associated with CV events in patients with CKD. Elevated serum RBP4 levels may indicate an increased risk of CV complications in CKD patients.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31999339</pmid><doi>10.1093/labmed/lmz104</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4501-5447</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-5027 |
| ispartof | Laboratory medicine, 2020-09, Vol.51 (5), p.491-497 |
| issn | 0007-5027 1943-7730 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2348803143 |
| source | Oxford Journals Online |
| subjects | Aged Analysis Cardiac patients Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality Care and treatment China - epidemiology Chronic kidney failure Female Health aspects Humans Kidney diseases Male Medical prognosis Middle Aged Mortality Proportional Hazards Models Prospective Studies Protein binding Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications Retinoids Retinol-Binding Proteins, Plasma - metabolism Type 2 diabetes |
| title | The Association between Serum Retinol-Binding Protein 4 Levels and Cardiovascular Events in Patients with Chronic Kidney Disease |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T18%3A20%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Association%20between%20Serum%20Retinol-Binding%20Protein%204%20Levels%20and%20Cardiovascular%20Events%20in%20Patients%20with%20Chronic%20Kidney%20Disease&rft.jtitle=Laboratory%20medicine&rft.au=Su,%20Yuhao&rft.date=2020-09-01&rft.volume=51&rft.issue=5&rft.spage=491&rft.epage=497&rft.pages=491-497&rft.issn=0007-5027&rft.eissn=1943-7730&rft_id=info:doi/10.1093/labmed/lmz104&rft_dat=%3Cgale_proqu%3EA697614174%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c460t-5a1e07994122adbbb4fcdd8e108c57dd195bbb84ff871cd2f13fa742042b5a003%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2473765751&rft_id=info:pmid/31999339&rft_galeid=A697614174&rft_oup_id=10.1093/labmed/lmz104&rfr_iscdi=true |