The incidence and etiology of sperm DNA fragmentation in the ejaculates of males with spinal cord injuries

Study design Retrospective descriptive study. Objectives To determine the incidence and probable etiology of sperm DNA fragmentation (SDF) in a sample of males with spinal cord injury (SCI). Setting Hospital in Toledo, Spain; University-based Genetics laboratory in Madrid, Spain. Methods Semen colle...

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Bibliographic Details
Published in:Spinal cord 2020-07, Vol.58 (7), p.803-810
Main Authors: Vargas-Baquero, Eduardo, Johnston, Stephen, Sánchez-Ramos, Antonio, Arévalo-Martín, Angel, Wilson, Richard, Gosálvez, Jaime
Format: Article
Language:English
Subjects:
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Anatomy
Biomedical and Life Sciences
Biomedicine
Degeneration
Deoxyribonucleic acid
DNA
DNA fragmentation
Etiology
Fragmentation
Genetics
Human Physiology
Injuries
Lesions
Males
Motility
Neurochemistry
Neuropsychology
Neurosciences
Oxidants
Oxidizing agents
Parameters
Semen
Sperm
Spermatozoa
Spinal cord injuries
Thorax
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Summary:Study design Retrospective descriptive study. Objectives To determine the incidence and probable etiology of sperm DNA fragmentation (SDF) in a sample of males with spinal cord injury (SCI). Setting Hospital in Toledo, Spain; University-based Genetics laboratory in Madrid, Spain. Methods Semen collected by vibro-stimulation from 27 males with various levels of spinal cord injury. Classical semen parameters, SDF, leukocytospermia and pro-oxidant capacity were assessed and compared with a cohort of normozoospermic fertile donors ( n  = 10). Results Males with SCI presented with lower semen quality compared with normozoospermic donors with respect to progressive motility ( p  = 0.0002), SDF ( p  
ISSN:1362-4393
1476-5624
DOI:10.1038/s41393-020-0426-6