Differences in coordination and timing of pre-reaching upper extremity movements may be an indicator of cerebral palsy in infants with stroke: A preliminary investigation

• Published in: Clinical biomechanics (Bristol) 2020-03, Vol.73, p.181-188
• Main Authors: Mazzarella, Julia, McNally, Mike, Chaudhari, Ajit M.W., Pan, Xueliang, Heathcock, Jill C.
• Format: Article
• Language: English
• Subjects: Biomechanical Phenomena; Cerebral palsy; Cerebral Palsy - complications; Cerebral Palsy - diagnosis; Cerebral Palsy - physiopathology; Child; Early identification; Female; Hemiplegia; Humans; Infant; Infant, Newborn; Kinematics; Male; Mechanical Phenomena; Movement; Neonatal stroke; Stroke - complications; Upper extremity; Upper Extremity - physiopathology
• ISSN: 0268-0033; 1879-1271
• DOI: 10.1016/j.clinbiomech.2019.12.024

Neonatal stroke is a leading cause of hemiplegic cerebral palsy that occurs around the time of birth. Infants are diagnosed with cerebral palsy when motor impairments become clinically apparent, months or years after the stroke. Tools/methods for identifying high risk or diagnosis of cerebral palsy in infancy are improving. We measured spatial and temporal kinematics of pre-reaching upper extremity movements in 2–3 month old infants with neonatal stroke and typical development. We aimed to evaluate the feasibility of applying kinematics in this population and collect preliminary data to explore (1) if asymmetries are present in the infants with neonatal stroke, particularly those with a later diagnosis of cerebral palsy, and (2) to compare differences in the timing and coordination of their movements to infants with typical development, and infants with stroke and no cerebral palsy. Participants were 21 full-term infants, 10 with stroke (4 who later received a cerebral palsy diagnosis) age 72.1 (SD 9.3) days, and 11 typically developing, age 74.3 (SD 9.3) days. Results showed that infants with stroke and cerebral palsy demonstrated significant asymmetry in the average movement length (p = 0.0089) and hand path length (p = 0.0275) between their involved and uninvolved sides and moved less frequently (p = 0.09) and slower (p = 0.041) than infants with stroke and no cerebral palsy. Results suggest that kinematic analysis might detect asymmetries and motor impairment indicative of hemiplegic cerebral palsy earlier than current assessments and that asymmetry in speed, length and frequency of arm movements may be early indicators. This study is preliminary, limiting interpretation of the results. •Early asymmetry may be observable in infants with neonatal stroke, cerebral palsy.•Less frequent, slower, and longer movements observed in affected limbs.•Infants with neonatal stroke, no cerebral palsy move similar to typical development.•Kinematic analysis might be used to identify risk for cerebral palsy.