Fabrication of nanopatterned PLGA films of curcumin and TPGS for skin cancer

• Published in: International journal of pharmaceutics 2020-03, Vol.578, p.119100-119100, Article 119100
• Main Authors: Malathi, S., Pavithra, P.S., Sridevi, S., Verma, Rama S.
• Format: Article
• Language: English
• Subjects: A431 cells; Curcumin; Nanopattern; Poly(lactic-co-glycolic) acid; Skin cancer
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2020.119100

[Display omitted] •PLGA NPFs (20nm) were fabricated by PDMS cast molding technique.•The surface of polymer NPFs were characterized by different techniques.•The hydrophilicity of NPFs significantly increased compared to unpattern films.•CTP-NPFs significantly inhibited the progression of squamous cell carcinoma. Squamous cell carcinoma treatment has limited therapeutic options and the incidence rate is increasing recently. In the present investigation, we developed poly(lactic-co-glycolic acid) (PLGA) nanopatterned films (NPFs) through poly dimethyl siloxane (PDMS) cast molding technique and explored its therapeutic efficacy in combination with curcumin and tocopherol poly (ethylene glycol) 1000 succinate (TPGS). Herein, we demonstrate the preparation and characterization of curcumin loaded tocopherol polyethylene glycol 1000 succinate stabilized poly (lactic-co-glycolic) acid nanopatterned films (CTP-NPFs). CTP-NPFs showed good in vitro cytotoxicity towards human skin cancer cell line (A431) when compared to that of unpattern films. CTP-NPFs effectively inhibited the progression of 7, 12-Dimethylbenz[a]anthracene (DMBA)/croton oil induced skin cancer in Swiss albino mice. The nanopatterned films could be used as an alternate treatment for skin cancer.