Deletion of the mouse X‐linked Prame gene causes germ cell reduction in spermatogenesis

Preferentially expressed antigen in melanoma (PRAME) is cancer/testis antigen and a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptor (RAR) for promoting cell proliferation and preventing cell apoptosis in cancer cells. The role of PRAME in testi...

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Bibliographic Details
Published in:Molecular reproduction and development 2020-06, Vol.87 (6), p.666-679
Main Authors: Lu, Chen, Yang, Mingyao, Rossi, Randall M., Wang, Aihua, Feitosa, Weber B., Diaz, Francisco J., Liu, Wan‐Sheng
Format: Article
Language:English
Subjects:
Antigens
Apoptosis
Cell proliferation
conditional knockout
Cyclin-dependent kinase inhibitor p21
DNA nucleotidylexotransferase
Gene deletion
germ cell
Germ cells
Immunofluorescence
Melanoma
mouse
Phenotypes
Prame
Retinoic acid receptors
Signal transduction
Spermatogenesis
Spermatogonia
Testes
Transcription
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Summary:Preferentially expressed antigen in melanoma (PRAME) is cancer/testis antigen and a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptor (RAR) for promoting cell proliferation and preventing cell apoptosis in cancer cells. The role of PRAME in testis and germline is unknown. We report here the generation and characterization of an X‐linked Prame conditional knockout (cKO) mouse. Although fertile, the testis size (p 
ISSN:1040-452X
1098-2795
DOI:10.1002/mrd.23324