Left ventricular stiffness in paediatric patients with end-stage kidney disease

Background We tested the hypothesis that myocardial stiffness is altered in paediatric patients with end-stage kidney disease (ESKD) and explored its association with clinical parameters of chronic kidney disease (CKD). Methods Thirty-five patients with ESKD (16 males) aged 17.5 ± 3 years old, 18/35...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2020-06, Vol.35 (6), p.1051-1060
Main Authors: Choi, Ann Wing-man, Fong, Nai-chung, Li, Vivian Wing-yi, Ho, Tsz-wai, Chan, Eugene Yu-hin, Ma, Alison Lap-tak, Cheung, Yiu-fai
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood pressure
Care and treatment
Chronic kidney failure
Dialysis
Doppler effect
Echocardiography
Echocardiography, Doppler
End-stage renal disease
Female
Health risk assessment
Heart
Heart ventricle, Left
Heart Ventricles - physiopathology
Hemodialysis
Humans
Kidney diseases
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - therapy
Kidney Transplantation
Male
Medical examination
Medicine
Medicine & Public Health
Multivariate analysis
Nephrology
Original Article
Patient outcomes
Pediatrics
Physiological aspects
Renal Dialysis
Renal replacement therapy
Retrospective Studies
Transplantation
Urology
Ventricle
Ventricular Dysfunction, Left - etiology
What’s new in Hypertension
Young Adult
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Summary:Background We tested the hypothesis that myocardial stiffness is altered in paediatric patients with end-stage kidney disease (ESKD) and explored its association with clinical parameters of chronic kidney disease (CKD). Methods Thirty-five patients with ESKD (16 males) aged 17.5 ± 3 years old, 18/35 of whom were receiving dialysis and 17 post kidney transplant, were studied. Left ventricular (LV) myocardial stiffness was determined by measurement of diastolic wall strain (DWS) and stiffness index (SI), while LV diastolic function was interrogated by pulsed-wave and tissue Doppler echocardiography. Results Compared with available literature data, both dialysis and transplanted patients had significantly lower DWS and greater SI, reduced transmitral early (E) to late diastolic velocity ratio and septal and lateral mitral annular early (e′) diastolic velocities, and greater septal and lateral E/e′ ratios (all p  
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-020-04484-9