Noninvasive assessment of oral lesions using elastic light single-scattering spectroscopy: a pilot study

Purpose In the present study, we investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as a noninvasive, adjunctive tool to differentiate between malignant and benign oral lesions in vivo. Methods ELSSS spectra were acquired from 52 oral lesions of 47 patient...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2020-05, Vol.277 (5), p.1467-1472
Main Authors: Sircan-Kucuksayan, Aslinur, Yaprak, Neslihan, Derin, Alper Tunga, Ozbudak, İrem Hicran, Turhan, Murat, Canpolat, Murat
Format: Article
Language:English
Subjects:
Biopsy
Head and Neck
Head and Neck Surgery
Humans
Medicine
Medicine & Public Health
Neurosurgery
Optical Fibers
Otorhinolaryngology
Pilot Projects
Sensitivity and Specificity
Spectrum Analysis
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Summary:Purpose In the present study, we investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as a noninvasive, adjunctive tool to differentiate between malignant and benign oral lesions in vivo. Methods ELSSS spectra were acquired from 52 oral lesions of 47 patients prior to surgical biopsy using a single optical fiber probe. The sign of the spectral slope was used as a diagnostic parameter and was compared to the histopathology findings to obtain sensitivity and specificity of the ELSSS system in differentiating between benign and malignant tissues. Results The sign of the spectral slope was positive for the benign tissues and negative for the malignant tissues. Nine malignant lesions and one high-grade dysplasia were correctly classified as cancerous. Six out of the ten low-grade dysplasia were correctly classified as cancerous, and four of them were misclassified as benign. Thirty benign lesions were correctly classified as benign, and two were misclassified as malignant. Our results indicate that the sign of the spectral slope enables the differentiation between malignant and benign oral lesions with a sensitivity of 80% and specificity of 94%. Conclusions ELSSS has the potential to be developed as an adjunctive screening tool in the noninvasive evaluation of oral lesions in vivo. This new diagnostic system may reduce the number of unnecessary biopsies.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-020-05824-z