Selective LC-MRM/SIM-MS based profiling of adrenal steroids reveals metabolic signatures of 17α-hydroxylase deficiency

[Display omitted] •A selective LC–MS-based profiling method of 27 serum adrenal steroids was developed.•The assay enables high-throughput sample analysis using a

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Bibliographic Details
Published in:The Journal of steroid biochemistry and molecular biology 2020-04, Vol.198, p.105615-105615, Article 105615
Main Authors: Lee, Chaelin, Kim, Jung Hee, Moon, Sun Joon, Shim, Jaeyoon, Kim, Hugh I., Choi, Man Ho
Format: Article
Language:English
Subjects:
17α-Hydroxylase
Adrenal cortex
Adrenal steroids
Adrenocorticotropic hormone
Androgens
Androstenedione
Congenital adrenal hyperplasia
Corticosteroids
Cushing syndrome
Dehydroepiandrosterone
Glucocorticoids
Hydroxylase
Hyperplasia
Ionization
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolism
Nervous system diseases
Phenotypes
Pituitary
Pregnenolone
Serum levels
Steroid hormones
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Description
Summary:[Display omitted] •A selective LC–MS-based profiling method of 27 serum adrenal steroids was developed.•The assay enables high-throughput sample analysis using a
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2020.105615