Follistatin expression in the central nervous system of the adult rat

•We investigated follistatin expression in the adult rat brain.•Follistatin was widely expressed throughout the central nervous system.•We detected follistatin expression in axons and astrocytes.•Follistatin plays important roles in adult brain. Follistatin was initially cloned as a monomeric polype...

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Bibliographic Details
Published in:Journal of chemical neuroanatomy 2020-04, Vol.105, p.101753-101753, Article 101753
Main Authors: Ogawa, Chikara, Mikawa, Sumiko, Yamashita, Kanna, Hayashi, Yutaro, Masumoto, Kazuma, Katou, Fuminori, Sato, Kohji
Format: Article
Language:English
Subjects:
Animals
Astrocytes - metabolism
Axon
Axons - metabolism
Brain - metabolism
Follistatin
Follistatin - metabolism
Immunohistochemistry
Male
Neurons - metabolism
Neuropil
Oligodendroglia - metabolism
Rats
Rats, Wistar
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Summary:•We investigated follistatin expression in the adult rat brain.•Follistatin was widely expressed throughout the central nervous system.•We detected follistatin expression in axons and astrocytes.•Follistatin plays important roles in adult brain. Follistatin was initially cloned as a monomeric polypeptide that inhibits the release of follicle-stimulating hormone. Although follistatin also plays pivotal roles in skeletal muscle hypertrophy and immunoregulation in the epididymis, little information is available regarding follistatin function in the adult central nervous system (CNS). Hence, we investigated follistatin expression in the adult rat CNS using immunohistochemistry. Follistatin was intensely expressed in most neurons and their axons. Furthermore, oligodendrocytes, ependymal cells, and some astrocytes also expressed follistatin protein. These data indicate that follistatin is widely expressed throughout the adult CNS. The abundant expression of follistatin in the adult brain suggests that this protein plays important roles in the CNS.
ISSN:0891-0618
1873-6300
DOI:10.1016/j.jchemneu.2020.101753