The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed-methods study

Background/objectives Weight-loss maintenance is challenging, and few succeed in the long term. This study aimed to explain how appetite-related hormones, adaptive thermogenesis, perceived hunger and stress influence weight-loss maintenance. Subjects/methods Fifteen adult women (age, 46.3 ± 9.5 year...

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Bibliographic Details
Published in:European journal of clinical nutrition 2020-04, Vol.74 (4), p.622-632
Main Authors: Thom, George, Dombrowski, Stephan U., Brosnahan, Naomi, Algindan, Yasmin Y., Rosario Lopez-Gonzalez, M., Roditi, Giles, Lean, Michael E. J., Malkova, Dalia
Format: Article
Language:English
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Adipose tissue
Appetite
Body weight
Body weight loss
Calorimetry
Care and treatment
Clinical Nutrition
Eating
Eating behavior
Epidemiology
Fasting
Ghrelin
Glucagon
Glucagon-like peptide 1
Hormones
Hunger
Internal Medicine
Leptin
Magnetic resonance imaging
Maintenance
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic rate
Metabolism
Mixed methods research
Obesity
Peptides
Psychological aspects
Psychological factors
Public Health
Reduction
Thermogenesis
Weight control
Weight loss measurement
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Summary:Background/objectives Weight-loss maintenance is challenging, and few succeed in the long term. This study aimed to explain how appetite-related hormones, adaptive thermogenesis, perceived hunger and stress influence weight-loss maintenance. Subjects/methods Fifteen adult women (age, 46.3 ± 9.5 years; BMI, 39.4 ± 4.3 kg/m 2 ) participated in a 24-month intervention, which included 3–5 months total diet replacement (825–853 kcal/d). Body weight and composition (Magnetic Resonance Imaging), resting metabolic rate (indirect calorimetry), and fasting plasma concentration of leptin, ghrelin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and growth differentiation factor 15 (GDF-15) were measured at baseline and after weight loss, around 6 months. Perceptions relating to weight-loss maintenance were explored using qualitative interviews. Results Mean (SD) changes in body weight (−13.8 ± 6.3 kg) and total adipose tissue (−11.5 ± 4.9 kg) were significant ( P  
ISSN:0954-3007
1476-5640
DOI:10.1038/s41430-020-0568-9