Nisin Z and lacticin 3147 improve efficacy of antibiotics against clinically significant bacteria

To determine if bacteriocins improve antibiotic efficacy. Deferred antagonism assays identified bacteriocins with activity. Growth curves and time kill assays demonstrated bactericidal activity of antimicrobial combinations, and checkerboard assays confirmed synergy. Methicillin-resistant -infected...

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Bibliographic Details
Published in:Future microbiology 2019-12, Vol.14 (18), p.1573-1587
Main Authors: Ellis, Jenna-Claire, Ross, Reynolds P, Hill, Colin
Format: Article
Language:English
Subjects:
Animals
Antagonism
Anti-Bacterial Agents - pharmacology
Antibiosis
Antibiotics
antimicrobial
Antimicrobial agents
Bacteria
Bacteria - drug effects
Bacteria - pathogenicity
Bactericidal activity
Bacteriocins
Bacteriocins - biosynthesis
Bacteriocins - pharmacology
Clinical significance
Drug resistance
Drug Synergism
Growth curves
lacticin 3147
Methicillin
Methicillin - pharmacology
Microbial Sensitivity Tests
Nisin
Nisin - analogs & derivatives
Nisin - pharmacology
nisin z
Nosocomial infections
pathogen
Pathogens
Penicillin
Peptides
Skin - drug effects
Skin - microbiology
Staphylococcus aureus
Staphylococcus infections
Swine
synergy
Vancomycin
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Summary:To determine if bacteriocins improve antibiotic efficacy. Deferred antagonism assays identified bacteriocins with activity. Growth curves and time kill assays demonstrated bactericidal activity of antimicrobial combinations, and checkerboard assays confirmed synergy. Methicillin-resistant -infected porcine skin model determined efficacy. Subinhibitory concentrations of lacticin with penicillin or vancomycin resulted in complete growth inhibition of strains and the improved inhibitory effect was apparent after 1 h. Nisin with methicillin proved more effective against methicillin-resistant than either antimicrobial alone, revealing partial synergy and significantly reduced pathogen numbers on porcine skin after 3 h compared with minimal inhibition for either antimicrobial alone. Nisin Z and lacticin 3147 may support the use of certain antibiotics and revive ineffective antibiotics.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2019-0153