Periodontitis and systemic markers of neurodegeneration: A case–control study

Aim To investigate whether periodontitis is associated with amyloid beta (Aβ) peptides and whether systemic inflammation could act as a potential mediator of this link. Materials and Methods A case–control study was designed including 75 patients with periodontitis (cases) and 75 age‐balanced and ge...

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Published in:Journal of clinical periodontology 2020-05, Vol.47 (5), p.561-571
Main Authors: Leira, Yago, Carballo, Álvaro, Orlandi, Marco, Aldrey, José Manuel, Pías‐Peleteiro, Juan Manuel, Moreno, Federico, Vázquez‐Vázquez, Laura, Campos, Francisco, D’Aiuto, Francesco, Castillo, José, Sobrino, Tomás, Blanco, Juan
Format: Article
Language:English
Subjects:
Amyloid beta-Peptides
Biomarkers
C-Reactive Protein - analysis
Case-Control Studies
C‐reactive protein
Dentistry
Gender
Gum disease
Humans
Interleukin 6
Neurodegeneration
Periodontitis
Periodontitis - complications
Serum levels
systemic inflammation
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Summary:Aim To investigate whether periodontitis is associated with amyloid beta (Aβ) peptides and whether systemic inflammation could act as a potential mediator of this link. Materials and Methods A case–control study was designed including 75 patients with periodontitis (cases) and 75 age‐balanced and gender‐matched participants without periodontitis (controls). Full‐mouth periodontal evaluation was performed in all participants. Demographic, clinical and behaviour data were also recorded. Fasting blood samples were collected, and serum levels of interleukin 6 (IL‐6), high‐sensitivity C‐reactive protein (hs‐CRP), Aβ1‐40 and Aβ1‐42 were determined. Results Cases showed higher levels of IL‐6 (8.7 ± 3.2 vs. 4.8 ± 0.5 pg/ml), hs‐CRP (3.3 ± 1.2 vs. 0.9 ± 0.7 mg/L), Aβ1‐40 (37.3 ± 6.0 vs. 30.3 ± 1.8 pg/ml) and Aβ1‐42 (54.5 ± 10.6 vs. 36.5 ± 10.0 pg/ml) when compared to controls (all p 
ISSN:0303-6979
1600-051X
DOI:10.1111/jcpe.13267