Targeting vasculogenic mimicry by phytochemicals: A potential opportunity for cancer therapy

Vasculogenic mimicry (VM) is regarded as a process where very aggressive cancer cells generate vascular‐like patterns without the presence of endothelial cells. It is considered as the main mark of malignant cancer and has pivotal role in cancer metastasis and progression in various types of cancers...

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Bibliographic Details
Published in:IUBMB life 2020-05, Vol.72 (5), p.825-841
Main Authors: Haiaty, Sanya, Rashidi, Mohammad‐Reza, Akbarzadeh, Maryam, Maroufi, Nazila F., Yousefi, Bahman, Nouri, Mohammad
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
cancers
Curcumin
Endothelial cells
Genistein
Ginsenosides
Metastases
Metastasis
Mimicry
Norcantharidin
Phytochemicals
Proanthocyanidins
Resveratrol
Signal transduction
signaling pathways
Triptolide
Tumors
vasculogenic mimicry
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Summary:Vasculogenic mimicry (VM) is regarded as a process where very aggressive cancer cells generate vascular‐like patterns without the presence of endothelial cells. It is considered as the main mark of malignant cancer and has pivotal role in cancer metastasis and progression in various types of cancers. On the other hand, resistance to the antiangiogenesis therapies leads to the cancer recurrence. Therefore, development of novel chemotherapies and their combinations is urgently needed for abolition of VM structures and also for better tumor therapy. Hence, identifying compounds that target VM structures might be superior therapeutic factors for cancers treatment and controlling the recurrence and metastasis. In recent times, naturally occurring compounds, especially phytochemicals have obtained great attention due to their safe properties. Phytochemicals are also capable of targeting VM structure and also their main signaling pathways. Consequently, in this review article, we illustrated key signaling pathways in VM, and the phytochemicals that affect these structures including curcumin, genistein, lycorine, luteolin, columbamine, triptolide, Paris polyphylla, dehydroeffusol, jatrorrhizine hydrochloride, grape seed proanthocyanidins, resveratrol, isoxanthohumol, dehydrocurvularine, galiellalactone, oxacyclododecindione, brucine, honokiol, ginsenoside Rg3, and norcantharidin. The recognition of these phytochemicals and their safety profile may lead to new therapeutic agents' development for VM elimination in different types of tumors.
ISSN:1521-6543
1521-6551
DOI:10.1002/iub.2233