Eriocalyxin B induces apoptosis in human triple negative breast cancer cells via inhibiting STAT3 activation and mitochondrial dysfunction

Eriocalyxin B (EriB), a potent ent-kaurene extracted from Isodon eriocalyx, has turned up as novel anti-cancer agent during recent years against a range of cancer types. TNBC (Triple negative breast cancer) is highly aggressive breast cancer, which is resistant towards current therapeutics due to ab...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2019-11, Vol.32 (6(Supplementary)), p.2843-2848
Main Authors: Riaz, Ammara, Rasul, Azhar, Hussain, Ghulam, Zubair, Muhammad, Samiullah, Khizar, Sarfraz, Iqra, Masood, Muqaddas, Jabeen, Farhat, Sultana, Tayyaba, Sultana, Salma
Format: Article
Language:English
Subjects:
Anopheles
Apoptosis
Breast cancer
Cancer cells
Cancer treatment
Novels
Therapeutics
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Summary:Eriocalyxin B (EriB), a potent ent-kaurene extracted from Isodon eriocalyx, has turned up as novel anti-cancer agent during recent years against a range of cancer types. TNBC (Triple negative breast cancer) is highly aggressive breast cancer, which is resistant towards current therapeutics due to absence of drug targets. Here, we have probed the molecular mechanism of EriB-induced apoptosis in TNBC (MDA-MB231) cells to check whether its anticancer activity is mediated by modulation of STAT3 and NF-ϰB. EriB induced apoptosis in MDA-MB231 cells via inhibiting NF-ϰBp65, STAT3 phosphorylation, increasing Bax/Bcl-2 ratio, MMP dissipation, and activation of caspase-3. These results provide a rationale for further in vivo investigations on EriB, which might also prove to be a potential drug candidate for developing novel therapeutics against TNBC.
ISSN:1011-601X
DOI:10.36721/PJPS.2019.32.6.SUP.2843-2848.1