Bio-inspired Maillard-Like reactions enable a simple and sensitive assay for colorimetric detection of methylglyoxal

A simple and selective assay for detecting methylglyoxal (MGO), a metabolite associated with diabetes, was developed by combining a bio-inspired chemical reaction with the anti-aggregation of gold nanoparticles. This assay could detect MGO at as low as 1 μM by the naked eye and 0.05 μM by UV/vis spe...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-07, Vol.51 (55), p.11026-11029
Main Authors: Wang, Shih-Ting, Lin, Yiyang, Spicer, Christopher D, Stevens, Molly M
Format: Article
Language:English
Subjects:
aldehydes
Assaying
Chemical reactions
Colorimetry
Colorimetry - methods
Diabetes
Humans
Ketones
Magnesium oxide
metabolites
Molecular Structure
nanogold
Nanoparticles
oxidative stress
Particle Size
Pyruvaldehyde - blood
Spectrometry
Spectrophotometry, Ultraviolet
Surface Properties
ultraviolet-visible spectroscopy
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Summary:A simple and selective assay for detecting methylglyoxal (MGO), a metabolite associated with diabetes, was developed by combining a bio-inspired chemical reaction with the anti-aggregation of gold nanoparticles. This assay could detect MGO at as low as 1 μM by the naked eye and 0.05 μM by UV/vis spectrometry, within the clinical range marking oxidative stress in diabetes, and demonstrated high selectivity over other physiologically relevant ketones and aldehydes.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c5cc02590g