A Contemporary Picture of Enterococcal Endocarditis

• Published in: Journal of the American College of Cardiology 2020-02, Vol.75 (5), p.482-494
• Main Authors: Hernández-Meneses, Marta, Ojeda-Burgos, Guillermo, Noureddine, Mariam, de la Torre Lima, Javier, Boado, María Victoria, Irurzun Zuazabal, Josu, Montejo, Miguel, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, Rodríguez Bailón, Isabel, María Cuende, Ana, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Izaguirre Yarza, Alberto, Merino, Esperanza, Plazas, Joaquín, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Llinares, Pedro, Miguez Rey, Enrique, Castro, Beatriz, García Rosado, Dácil, Lacalzada, Juan, Nassar, Ibrahim, Plata Ciezar, Antonio, de la Hera, Jesús, León Arguero, Víctor, López Menéndez, José, Mencia Bajo, Pilar, Paya Martínez, Begoña, Telenti Asensio, Mauricio, Falces, Carlos, Moreno, Asunción, Sitges, Marta, Soy, Dolors, Tolosana, José M., Vidal, Bárbara, Bermejo, Javier, Celemín, Daniel, Cuerpo Caballero, Gregorio, Delgado Montero, Antonia, Kestler Hernández, Martha, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinto, Ángel, Verde Moreno, Eduardo, Moreno, Mar, Rial Bastón, Verónica, Agüero Balbín, Jesús, Armiñanzas Castillo, Carlos, Arnaiz, Ana, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Gómez Izquierdo, Rubén, González, Jesús, Ramos, Antonio, Sánchez Romero, Isabel, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, Barquero, José Miguel, de Cueto, Marina, Gálvez Acebal, Juan, López, Francisco, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Pons, Guillem, Regueiro, Benito, Vega, Marino, Cordo Mollar, José, Gainzarain Arana, Juan Carlos, García Uriarte, Oscar, Ortiz de Zárate, Zuriñe, Arribas Leal, José Ma, Aramburu, Javier, Moreno Rodríguez, Anai, Tarabini-Castellani, Paola, Maicas Bellido, Carolina, Cascales Alcolea, Eva, Martínez, Julián Navarro, Núñez Morcillo, Juana, Aured Guallar, Carmen, Palacián Ruiz, Ma Pilar, Viqueira González, Monserrat, Vidal Bonet, Laura, Bellón Munera, Ma Carmen, Badía, Cristina, Marrero Santiago, Héctor, Pisos Álamo, Elena, Chaves, Fernando, de Cossío, Santiago, López Medrano, Francisco, Solera, Javier, Grillo, Sara
• Format: Article
• Language: English
• Subjects: Aged; Cohort Studies; Endocarditis, Bacterial - epidemiology; Endocarditis, Bacterial - microbiology; enterococci; Enterococcus faecalis - isolation & purification; epidemiology; Female; Gram-Positive Bacterial Infections - epidemiology; Gram-Positive Bacterial Infections - microbiology; heart failure; Humans; infective endocarditis; Male; Middle Aged; prosthetic valves; relapses; Spain - epidemiology
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2019.11.047

Enterococcal endocarditis (EE) is a growing entity in Western countries. However, quality data from large studies is lacking. The purpose of this study was to describe the characteristics and analyze the prognostic factors of EE in the GAMES cohort. This was a post hoc analysis of a prospectively collected cohort of patients from 35 Spanish centers from 2008 to 2016. Characteristics and outcomes of 516 cases of EE were compared with those of 3,308 cases of nonenterococcal endocarditis (NEE). Logistic regression and Cox proportional hazards regression analysis were performed to investigate risk factors for in-hospital and 1-year mortality, as well as relapses. Patients with EE were significantly older; more frequently presented chronic lung disease, chronic heart failure, prior endocarditis, and degenerative valve disease; and had higher median age-adjusted Charlson score. EE more frequently involved the aortic valve and prosthesis (64.3% vs. 46.7%; p