Photodisinfection effects of silver sulfadiazine nanoliposomes doped-curcumin on Acinetobacter baumannii : a mouse model

To evaluate the antimicrobial effects of photoexcited silver sulfadiazine nanoliposomes (AgSD-NLs) doped by curcumin (AgSD-NLs@Cur) on . Following characterization, the cytotoxic and hemolytic activities of AgSD-NLs@Cur were evaluated. The antimicrobial activities of AgSD-NLs@Cur-mediated antimicrob...

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Published in:Nanomedicine (London, England) England), 2020-02, Vol.15 (5), p.437-452
Main Authors: Pourhajibagher, Maryam, Partoazar, Alireza, Alaeddini, Mojgan, Etemad-Moghadam, Shahroo, Bahador, Abbas
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Drug resistance
Fibroblasts
Fourier transforms
Hypotheses
Infections
Laboratories
Light emitting diodes
Microorganisms
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Summary:To evaluate the antimicrobial effects of photoexcited silver sulfadiazine nanoliposomes (AgSD-NLs) doped by curcumin (AgSD-NLs@Cur) on . Following characterization, the cytotoxic and hemolytic activities of AgSD-NLs@Cur were evaluated. The antimicrobial activities of AgSD-NLs@Cur-mediated antimicrobial photodynamic therapy (aPDT) were determined. Histopathological examination of the burn wound sites of infected mice treated with photoexcited AgSD-NLs@Cur was assessed. No significant cytotoxic and hemolytic activities were observed. There was a decrease in the count in planktonic and biofilm forms and the gene expression level using AgSD-NLs@Cur-aPDT (p < 0.05). Histopathological analysis indicated the epidermis developed markedly and the bacterial load decreased significantly after aPDT. Photoexcited AgSD-NLs@Cur has an antimicrobial potential against .
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2019-0315