Effect of probiotics in experimental otitis media with effusion

• Published in: International journal of pediatric otorhinolaryngology 2020-05, Vol.132, p.109922-109922, Article 109922
• Main Authors: Kaytez, Selda Kargin, Ocal, Ramazan, Yumusak, Nihat, Celik, Hatiçe, Arslan, Necmi, Ibas, Mustafa
• Format: Article
• Language: English
• Subjects: Histamine-induced otitis media; Lactobacillus reuteri; Otitis media with effusion; Probiotics
• ISSN: 0165-5876; 1872-8464
• DOI: 10.1016/j.ijporl.2020.109922

The article's aim was to investigate the effects of probiotics in the experimental otitis media with effusion. Twenty-four male Wistar albino rats were used. They were divided into four groups. Experimental otitis media with effusion was created by intratympanic histamine injection. The effusion was confirmed by otomicroscopic examination 24 h after injection. Group 1; did not receive any treatment, group 2; received probiotics for 7 days after the detection of effusion, group 3; received probiotics for 7 days prior to injection of histamine, group 4; received probiotics for 7 days before injection of histamine and 7 days after detection of effusion. After detection of effusion, animals were sacrificed. Otomicroscopic evaluation was done to determine the effusion. In histopathological examination neutrophil leukocyte counts were determined in 25 areas of the sub-mucosa of the temporal bulla. The otomicroscopic ear effusions’ healing rate in group 1 was 10%, in group 2 was 25%, in group 3 was 50%, and in group 4 was 100% (p