Asymmetric Synthesis of Rugulotrosin A

A new approach was developed to construct the tetrahydroxanthone by a Knoevenagel condensation/6π-electronic cyclization/aromatization cascade starting from readily available cyclohexane-1,3-diones and unsaturated aldehydes. This strategy provides a new solution for the preparation of monomeric tetr...

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Bibliographic Details
Published in:Organic letters 2020-02, Vol.22 (4), p.1485-1489
Main Authors: Chen, Jianhua, Li, Yayue, Xiao, Zheming, He, Haibing, Gao, Shuanhu
Format: Article
Language:English
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Summary:A new approach was developed to construct the tetrahydroxanthone by a Knoevenagel condensation/6π-electronic cyclization/aromatization cascade starting from readily available cyclohexane-1,3-diones and unsaturated aldehydes. This strategy provides a new solution for the preparation of monomeric tetrahydroxanthones bearing different functional groups at C-12. As a synthetic application, the asymmetric formal synthesis of rugulotrosin A was achieved.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c00063