A triple-helix molecular switch photoelectrochemical biosensor for ultrasensitive microRNA detection based on position-controllable CdS//CdTe signal enhancement and switching

Herein, a triple-helix molecular switch photoelectrochemical (PEC) biosensor is developed for ultrasensitive and selective detection of microRNA based on position-controllable CdS//CdTe signal enhancement and switching accompanying the signal amplification of a three-dimensional DNA walking machine....

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-03, Vol.56 (19), p.299-2912
Main Authors: Geng, Wenchao, Yang, Ruiying
Format: Article
Language:English
Subjects:
Absorption spectra
Biosensing Techniques
Biosensors
Cadmium Compounds - chemistry
Cadmium sulfide
Cadmium tellurides
DNA - chemistry
Electrochemical analysis
Electrochemical Techniques - instrumentation
Gold
Image detection
Limit of Detection
MicroRNAs
MicroRNAs - analysis
Molecular machines
Optimization
Photochemical Processes
Ribonucleic acid
RNA
Selectivity
Silver
Sulfides - chemistry
Switching
Tellurium - chemistry
Walking machines
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Summary:Herein, a triple-helix molecular switch photoelectrochemical (PEC) biosensor is developed for ultrasensitive and selective detection of microRNA based on position-controllable CdS//CdTe signal enhancement and switching accompanying the signal amplification of a three-dimensional DNA walking machine. The developed PEC biosensor exhibits excellent analytical performance for microRNA-141 detection with a wide linear range from 5 aM to 100 fM, a low detection limit of 1.3 aM and outstanding selectivity. A triple-helix molecular switch photoelectrochemical biosensor is developed for ultrasensitive microRNA detection based on position-controllable CdS//CdTe signal enhancement and switching.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc09877a