In vitro antioxidant and antimicrobial activities, and in vivo anti-inflammatory activity of crude and fractionated PHNQs from sea urchin (Evechinus chloroticus)

•E. chloroticus polyhydroxyl-1,4-naphthoquinones were extracted and fractionated.•In vitro antioxidant activities were determined by ORAC, DPPH and FRAP assays.•E. chloroticus PHNQ extracts exhibited antimicrobial activity.•The extracts exhibited anti-inflammatory activity comparable to Celecoxib. T...

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Bibliographic Details
Published in:Food chemistry 2020-06, Vol.316, p.126339-126339, Article 126339
Main Authors: Hou, Yakun, Carne, Alan, McConnell, Michelle, Bekhit, Adnan A., Mros, Sonya, Amagase, Kikuko, Bekhit, Alaa El-Din A.
Format: Article
Language:English
Subjects:
4-naphthoquinone (PHNQ)
Anti-inflammation
Anti-microbial
Antioxidant
Evechinus chloroticus
Polyhydroxyl-1
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Summary:•E. chloroticus polyhydroxyl-1,4-naphthoquinones were extracted and fractionated.•In vitro antioxidant activities were determined by ORAC, DPPH and FRAP assays.•E. chloroticus PHNQ extracts exhibited antimicrobial activity.•The extracts exhibited anti-inflammatory activity comparable to Celecoxib. This study investigated the bioactivities of polyhydroxyl-1,4-naphthoquinone (PHNQ) extracts from Evechinus chloroticus shell waste. PHNQs were extracted from E. chloroticus shells and spines using different solvents and the crude extracts were fractionated by HPLC. The antioxidant activity of the PHNQ extracts were evaluated by the DPPH, ABTS, ORAC and FRAP assays. Ethyl acetate was the best extraction solvent and spine extracts showed better antioxidant activity than shell extracts (p 
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2020.126339