Modulation of cyclic topology toward enhanced drug delivery, from linear and tadpole-like to dumbbell-shaped copolymers

In this study, an efficient strategy for the synthesis of dumbbell-shaped amphiphilic copolymers with cyclic moieties as the two bells was developed and the enhanced performance of dumbbell-shaped copolymers for controlled drug release because of the simultaneous introduction of two macrocycles was...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-03, Vol.56 (2), p.33-36
Main Authors: Kang, Guiying, Liu, Yuping, Li, Lingxia, Sun, Lu, Ma, Wei, Meng, Chao, Ma, Liwei, Zheng, Guohua, Chang, Cong, Wei, Hua
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - pharmacology
Cell Proliferation - drug effects
Chemical synthesis
Copolymers
Dose-Response Relationship, Drug
Doxorubicin - chemistry
Doxorubicin - pharmacology
Drug Delivery Systems
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Macrocyclic Compounds - chemical synthesis
Macrocyclic Compounds - chemistry
Micelles
Molecular Structure
Performance enhancement
Polymers - chemical synthesis
Polymers - chemistry
Structure-Activity Relationship
Surface-Active Agents - chemical synthesis
Surface-Active Agents - chemistry
Topology
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Summary:In this study, an efficient strategy for the synthesis of dumbbell-shaped amphiphilic copolymers with cyclic moieties as the two bells was developed and the enhanced performance of dumbbell-shaped copolymers for controlled drug release because of the simultaneous introduction of two macrocycles was disclosed. We reported herein the synthesis of a novel dumbbell-shaped amphiphilic copolymer with two macrocycles-based bells, and revealed the better performance of this polymer construct than those of the linear and tadpole-like analogues for drug release.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc09878j