Exploring the putative interactions between chronic kidney disease and chronic periodontitis

Chronic kidney disease (CKD) and chronic periodontitis (CP) are both common diseases, which are found disproportionately comorbid with each other and have been reported to have a detrimental effect on the progression of each respective disease. They have an overlap in risk factors and both are a sou...

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Bibliographic Details
Published in:Critical reviews in microbiology 2020-01, Vol.46 (1), p.61-77
Main Authors: Hickey, Niall A., Shalamanova, Liliana, Whitehead, Kathryn A., Dempsey-Hibbert, Nina, van der Gast, Christopher, Taylor, Rebecca L.
Format: Article
Language:English
Subjects:
Bacteremia - microbiology
Bacteria - metabolism
Chronic kidney disease
chronic periodontitis
Chronic Periodontitis - microbiology
Chronic Periodontitis - pathology
comorbidities
Comorbidity
Humans
Inflammation - pathology
Mouth Mucosa - microbiology
periodontal bacteria
Renal Insufficiency, Chronic - microbiology
Renal Insufficiency, Chronic - pathology
Risk Factors
systemic interactions
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Summary:Chronic kidney disease (CKD) and chronic periodontitis (CP) are both common diseases, which are found disproportionately comorbid with each other and have been reported to have a detrimental effect on the progression of each respective disease. They have an overlap in risk factors and both are a source of systemic inflammation along with a wide selection of immunological and non-specific effects that can affect the body over the lifespan of the conditions. Previous studies have investigated the directionality of the relationship between these two diseases; however, there is a lack of literature that has examined how these diseases may be interacting at the localized and systemic level. This review discusses how oral microorganisms have the ability to translocate and have distal effects and provides evidence for microbial involvement in a systemic disease. Furthermore, it summarizes the reported local and systemic effects of CKD and CP and discusses how the interaction of these effects may be responsible for directionality associations reported.
ISSN:1040-841X
1549-7828
DOI:10.1080/1040841X.2020.1724872