Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics

This review summarizes single vs dual antibiotic cement literature, evaluating for synergistic activity with dual antibiotics. A systematic review was performed for literature regarding dual antibiotics in cement, identifying 13 studies to include for review. Many in vitro studies reported higher el...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of arthroplasty 2020-03, Vol.35 (3), p.S19-S23
Main Authors: Mohamed, Nequesha S., Wilkie, Wayne A., Remily, Ethan A., Nace, James, Delanois, Ronald E., Browne, James A.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
antibiotic cement
antibiotic elution
antibiotic synergy
Bacteria
Bone Cements
dual antibiotic cement
dual antibiotics
Humans
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c356t-da08f18c0b74911878cc03968396a14a298fae6f9897f48adf0a6b0cf492e3103
cites cdi_FETCH-LOGICAL-c356t-da08f18c0b74911878cc03968396a14a298fae6f9897f48adf0a6b0cf492e3103
container_end_page S23
container_issue 3
container_start_page S19
container_title The Journal of arthroplasty
container_volume 35
creator Mohamed, Nequesha S.
Wilkie, Wayne A.
Remily, Ethan A.
Nace, James
Delanois, Ronald E.
Browne, James A.
description This review summarizes single vs dual antibiotic cement literature, evaluating for synergistic activity with dual antibiotics. A systematic review was performed for literature regarding dual antibiotics in cement, identifying 13 studies to include for review. Many in vitro studies reported higher elution from cement and/or improved bacteria inhibition with dual antibiotics, typically at higher dosages with a manual mixing technique. Limited clinical data from hip hemiarthroplasties and spacers demonstrated that dual antibiotics were associated with improved infection prevention and higher intra-articular antibiotic concentrations. In addition to broader pathogen coverage, several studies document synergy of elution and increased antibacterial activity when dual antibiotics are added to cement. Limited clinical evidence suggests that dual antibiotic cement may be associated with reduced infection rates.
doi_str_mv 10.1016/j.arth.2019.11.002
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2354142930</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S088354031931040X</els_id><sourcerecordid>2354142930</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-da08f18c0b74911878cc03968396a14a298fae6f9897f48adf0a6b0cf492e3103</originalsourceid><addsrcrecordid>eNp9kE1Lw0AQhhdRbP34Ax4kRy-JM7ubdCNepH6C4EE9L9vNbLslTXQ3FfrvTWjVm4dhYHjeF-Zh7AwhQ8DicpmZ0C0yDlhmiBkA32NjzAVPlYRin41BKZHmEsSIHcW4BEDMc3nIRoKDLBTPx-zhpun8zLedt8l00XpLV8nbgpLXTUNh7uNwv3OObJe0Lnn1zbym5Csmt2tTJ3_ZeMIOnKkjne72MXu_v3ubPqbPLw9P05vn1Iq86NLKgHKoLMwmskRUE2UtiLJQ_RiUhpfKGSpcqcqJk8pUDkwxA-tkyUkgiGN2se39CO3nmmKnVz5aqmvTULuOmotcouSlGFC-RW1oYwzk9EfwKxM2GkEPAvVSDwL1IFAj6l5gHzrf9a9nK6p-Iz_GeuB6C1D_5ZenoKP11FiqfOgt6ar1__V_A6ftgBs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2354142930</pqid></control><display><type>article</type><title>Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics</title><source>ScienceDirect Freedom Collection</source><creator>Mohamed, Nequesha S. ; Wilkie, Wayne A. ; Remily, Ethan A. ; Nace, James ; Delanois, Ronald E. ; Browne, James A.</creator><creatorcontrib>Mohamed, Nequesha S. ; Wilkie, Wayne A. ; Remily, Ethan A. ; Nace, James ; Delanois, Ronald E. ; Browne, James A.</creatorcontrib><description>This review summarizes single vs dual antibiotic cement literature, evaluating for synergistic activity with dual antibiotics. A systematic review was performed for literature regarding dual antibiotics in cement, identifying 13 studies to include for review. Many in vitro studies reported higher elution from cement and/or improved bacteria inhibition with dual antibiotics, typically at higher dosages with a manual mixing technique. Limited clinical data from hip hemiarthroplasties and spacers demonstrated that dual antibiotics were associated with improved infection prevention and higher intra-articular antibiotic concentrations. In addition to broader pathogen coverage, several studies document synergy of elution and increased antibacterial activity when dual antibiotics are added to cement. Limited clinical evidence suggests that dual antibiotic cement may be associated with reduced infection rates.</description><identifier>ISSN: 0883-5403</identifier><identifier>EISSN: 1532-8406</identifier><identifier>DOI: 10.1016/j.arth.2019.11.002</identifier><identifier>PMID: 32046825</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; antibiotic cement ; antibiotic elution ; antibiotic synergy ; Bacteria ; Bone Cements ; dual antibiotic cement ; dual antibiotics ; Humans</subject><ispartof>The Journal of arthroplasty, 2020-03, Vol.35 (3), p.S19-S23</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-da08f18c0b74911878cc03968396a14a298fae6f9897f48adf0a6b0cf492e3103</citedby><cites>FETCH-LOGICAL-c356t-da08f18c0b74911878cc03968396a14a298fae6f9897f48adf0a6b0cf492e3103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32046825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed, Nequesha S.</creatorcontrib><creatorcontrib>Wilkie, Wayne A.</creatorcontrib><creatorcontrib>Remily, Ethan A.</creatorcontrib><creatorcontrib>Nace, James</creatorcontrib><creatorcontrib>Delanois, Ronald E.</creatorcontrib><creatorcontrib>Browne, James A.</creatorcontrib><title>Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics</title><title>The Journal of arthroplasty</title><addtitle>J Arthroplasty</addtitle><description>This review summarizes single vs dual antibiotic cement literature, evaluating for synergistic activity with dual antibiotics. A systematic review was performed for literature regarding dual antibiotics in cement, identifying 13 studies to include for review. Many in vitro studies reported higher elution from cement and/or improved bacteria inhibition with dual antibiotics, typically at higher dosages with a manual mixing technique. Limited clinical data from hip hemiarthroplasties and spacers demonstrated that dual antibiotics were associated with improved infection prevention and higher intra-articular antibiotic concentrations. In addition to broader pathogen coverage, several studies document synergy of elution and increased antibacterial activity when dual antibiotics are added to cement. Limited clinical evidence suggests that dual antibiotic cement may be associated with reduced infection rates.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>antibiotic cement</subject><subject>antibiotic elution</subject><subject>antibiotic synergy</subject><subject>Bacteria</subject><subject>Bone Cements</subject><subject>dual antibiotic cement</subject><subject>dual antibiotics</subject><subject>Humans</subject><issn>0883-5403</issn><issn>1532-8406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1Lw0AQhhdRbP34Ax4kRy-JM7ubdCNepH6C4EE9L9vNbLslTXQ3FfrvTWjVm4dhYHjeF-Zh7AwhQ8DicpmZ0C0yDlhmiBkA32NjzAVPlYRin41BKZHmEsSIHcW4BEDMc3nIRoKDLBTPx-zhpun8zLedt8l00XpLV8nbgpLXTUNh7uNwv3OObJe0Lnn1zbym5Csmt2tTJ3_ZeMIOnKkjne72MXu_v3ubPqbPLw9P05vn1Iq86NLKgHKoLMwmskRUE2UtiLJQ_RiUhpfKGSpcqcqJk8pUDkwxA-tkyUkgiGN2se39CO3nmmKnVz5aqmvTULuOmotcouSlGFC-RW1oYwzk9EfwKxM2GkEPAvVSDwL1IFAj6l5gHzrf9a9nK6p-Iz_GeuB6C1D_5ZenoKP11FiqfOgt6ar1__V_A6ftgBs</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Mohamed, Nequesha S.</creator><creator>Wilkie, Wayne A.</creator><creator>Remily, Ethan A.</creator><creator>Nace, James</creator><creator>Delanois, Ronald E.</creator><creator>Browne, James A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202003</creationdate><title>Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics</title><author>Mohamed, Nequesha S. ; Wilkie, Wayne A. ; Remily, Ethan A. ; Nace, James ; Delanois, Ronald E. ; Browne, James A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-da08f18c0b74911878cc03968396a14a298fae6f9897f48adf0a6b0cf492e3103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>antibiotic cement</topic><topic>antibiotic elution</topic><topic>antibiotic synergy</topic><topic>Bacteria</topic><topic>Bone Cements</topic><topic>dual antibiotic cement</topic><topic>dual antibiotics</topic><topic>Humans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed, Nequesha S.</creatorcontrib><creatorcontrib>Wilkie, Wayne A.</creatorcontrib><creatorcontrib>Remily, Ethan A.</creatorcontrib><creatorcontrib>Nace, James</creatorcontrib><creatorcontrib>Delanois, Ronald E.</creatorcontrib><creatorcontrib>Browne, James A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of arthroplasty</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed, Nequesha S.</au><au>Wilkie, Wayne A.</au><au>Remily, Ethan A.</au><au>Nace, James</au><au>Delanois, Ronald E.</au><au>Browne, James A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics</atitle><jtitle>The Journal of arthroplasty</jtitle><addtitle>J Arthroplasty</addtitle><date>2020-03</date><risdate>2020</risdate><volume>35</volume><issue>3</issue><spage>S19</spage><epage>S23</epage><pages>S19-S23</pages><issn>0883-5403</issn><eissn>1532-8406</eissn><abstract>This review summarizes single vs dual antibiotic cement literature, evaluating for synergistic activity with dual antibiotics. A systematic review was performed for literature regarding dual antibiotics in cement, identifying 13 studies to include for review. Many in vitro studies reported higher elution from cement and/or improved bacteria inhibition with dual antibiotics, typically at higher dosages with a manual mixing technique. Limited clinical data from hip hemiarthroplasties and spacers demonstrated that dual antibiotics were associated with improved infection prevention and higher intra-articular antibiotic concentrations. In addition to broader pathogen coverage, several studies document synergy of elution and increased antibacterial activity when dual antibiotics are added to cement. Limited clinical evidence suggests that dual antibiotic cement may be associated with reduced infection rates.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32046825</pmid><doi>10.1016/j.arth.2019.11.002</doi></addata></record>
fulltext fulltext
identifier ISSN: 0883-5403
ispartof The Journal of arthroplasty, 2020-03, Vol.35 (3), p.S19-S23
issn 0883-5403
1532-8406
language eng
recordid cdi_proquest_miscellaneous_2354142930
source ScienceDirect Freedom Collection
subjects Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
antibiotic cement
antibiotic elution
antibiotic synergy
Bacteria
Bone Cements
dual antibiotic cement
dual antibiotics
Humans
title Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T04%3A36%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antibiotic%20Choice:%20The%20Synergistic%20Effect%20of%20Single%20vs%20Dual%20Antibiotics&rft.jtitle=The%20Journal%20of%20arthroplasty&rft.au=Mohamed,%20Nequesha%20S.&rft.date=2020-03&rft.volume=35&rft.issue=3&rft.spage=S19&rft.epage=S23&rft.pages=S19-S23&rft.issn=0883-5403&rft.eissn=1532-8406&rft_id=info:doi/10.1016/j.arth.2019.11.002&rft_dat=%3Cproquest_cross%3E2354142930%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c356t-da08f18c0b74911878cc03968396a14a298fae6f9897f48adf0a6b0cf492e3103%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2354142930&rft_id=info:pmid/32046825&rfr_iscdi=true