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Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer
Background Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patient...
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| Published in: | Annals of surgical oncology 2020-08, Vol.27 (8), p.3064-3070 |
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| container_title | Annals of surgical oncology |
| container_volume | 27 |
| creator | Maruyama, Suguru Kawaguchi, Yoshihiko Akaike, Hidenori Shoda, Katsutoshi Saito, Ryo Shimizu, Hiroki Furuya, Shinji Hosomura, Naohiro Amemiya, Hidetake Kawaida, Hiromichi Sudo, Makoto Inoue, Shingo Kono, Hiroshi Ichikawa, Daisuke |
| description | Background
Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patients with gastric cancer. In addition, the mechanisms underlying the effect of postoperative complications on outcomes remain to be elucidated. We hypothesized that immunosuppression by postoperative complications may affect long-term outcomes in patients with esophageal cancer.
Methods
In this retrospective study, we assessed in 153 patients with esophageal cancer who underwent curative subtotal esophagectomy at our hospital and examined the correlation between postoperative complications, and multiple clinicopathological factors, and long-term outcomes with the patients stratified by total lymphocyte count (TLC).
Results
The median preoperative TLC was 1432. A total of 115 patients (75.2%) had a TLC of ≥ 1000/μL (high TLC group), and the remaining 38 patients (24.8%) had a TLC of |
| doi_str_mv | 10.1245/s10434-020-08245-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2354150656</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2419780813</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-e03910b329bc54fe127ffc124cbf4a497da05eed3ef778441ae7b0978dc738f3</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxSMEon-_AAdkiQuXwDi2E-eIVoVW2qp72LvlOJNdV4kd7ATUb8_AFpA4cBr7-TdvbL-ieMPhA6-k-pg5SCFLqKAETUKpXxTnXJEka81f0hpqXbZVrc6Ki5wfAXgjQL0uzkQFUkML58XTLuYlzpjs4r8h28RpHr2jTQyZHS1J9z74yY7sbpqtW1gMbBvDodxjmtguxUOI2WfmAwHTGmKPg3cew8J25EI1s-9-ObKbHOejPSA5bWxwmK6KV4MdM14_18ti__lmv7kttw9f7jaftqUTjVpKBNFy6ETVdk7JAXnVDIOj97tukFa2TW9BIfYCh6bRUnKLTQdto3vXCD2Iy-L9yXZO8euKeTGTzw7H0QaMazaVUJIrqFVN6Lt_0Me4pkCXM5XkZAmaC6KqE-VSzDnhYOZEH5SeDAfzMxdzysVQLuZXLkZT09tn67WbsP_T8jsIAsQJyHQUDpj-zv6P7Q8Zx5nn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2419780813</pqid></control><display><type>article</type><title>Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer</title><source>Springer Nature</source><creator>Maruyama, Suguru ; Kawaguchi, Yoshihiko ; Akaike, Hidenori ; Shoda, Katsutoshi ; Saito, Ryo ; Shimizu, Hiroki ; Furuya, Shinji ; Hosomura, Naohiro ; Amemiya, Hidetake ; Kawaida, Hiromichi ; Sudo, Makoto ; Inoue, Shingo ; Kono, Hiroshi ; Ichikawa, Daisuke</creator><creatorcontrib>Maruyama, Suguru ; Kawaguchi, Yoshihiko ; Akaike, Hidenori ; Shoda, Katsutoshi ; Saito, Ryo ; Shimizu, Hiroki ; Furuya, Shinji ; Hosomura, Naohiro ; Amemiya, Hidetake ; Kawaida, Hiromichi ; Sudo, Makoto ; Inoue, Shingo ; Kono, Hiroshi ; Ichikawa, Daisuke</creatorcontrib><description>Background
Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patients with gastric cancer. In addition, the mechanisms underlying the effect of postoperative complications on outcomes remain to be elucidated. We hypothesized that immunosuppression by postoperative complications may affect long-term outcomes in patients with esophageal cancer.
Methods
In this retrospective study, we assessed in 153 patients with esophageal cancer who underwent curative subtotal esophagectomy at our hospital and examined the correlation between postoperative complications, and multiple clinicopathological factors, and long-term outcomes with the patients stratified by total lymphocyte count (TLC).
Results
The median preoperative TLC was 1432. A total of 115 patients (75.2%) had a TLC of ≥ 1000/μL (high TLC group), and the remaining 38 patients (24.8%) had a TLC of < 1000/μL (low TLC group). Postoperative complications occurred in 39 of 153 cases (25.5%). There was no significant correlation between postoperative complications and any of the clinicopathological factors in either group. In the high TLC group, patients with postoperative complications had significantly lower overall and disease-free survival rates compared with those without complications (
p
< 0.001 and
p
< 0.01, respectively). In the low TLC group, no survival difference between patients with and without postoperative complications was observed.
Conclusions
Postoperative complications may have a minimal impact on long-term outcomes in immunodeficient patients.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-020-08245-8</identifier><identifier>PMID: 32048090</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Cell number ; Esophageal cancer ; Esophageal Neoplasms - surgery ; Esophagectomy - adverse effects ; Esophagus ; Gastrectomy ; Gastrectomy - adverse effects ; Gastric cancer ; Humans ; Immunodeficiency ; Immunosuppression ; Lymphocytes ; Medical prognosis ; Medicine ; Medicine & Public Health ; Oncology ; Postoperative Complications - etiology ; Postoperative period ; Prognosis ; Retrospective Studies ; Splenectomy ; Stomach Neoplasms - surgery ; Surgery ; Surgical Oncology ; Survival Rate ; Thoracic Oncology</subject><ispartof>Annals of surgical oncology, 2020-08, Vol.27 (8), p.3064-3070</ispartof><rights>Society of Surgical Oncology 2020</rights><rights>Society of Surgical Oncology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e03910b329bc54fe127ffc124cbf4a497da05eed3ef778441ae7b0978dc738f3</citedby><cites>FETCH-LOGICAL-c375t-e03910b329bc54fe127ffc124cbf4a497da05eed3ef778441ae7b0978dc738f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32048090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maruyama, Suguru</creatorcontrib><creatorcontrib>Kawaguchi, Yoshihiko</creatorcontrib><creatorcontrib>Akaike, Hidenori</creatorcontrib><creatorcontrib>Shoda, Katsutoshi</creatorcontrib><creatorcontrib>Saito, Ryo</creatorcontrib><creatorcontrib>Shimizu, Hiroki</creatorcontrib><creatorcontrib>Furuya, Shinji</creatorcontrib><creatorcontrib>Hosomura, Naohiro</creatorcontrib><creatorcontrib>Amemiya, Hidetake</creatorcontrib><creatorcontrib>Kawaida, Hiromichi</creatorcontrib><creatorcontrib>Sudo, Makoto</creatorcontrib><creatorcontrib>Inoue, Shingo</creatorcontrib><creatorcontrib>Kono, Hiroshi</creatorcontrib><creatorcontrib>Ichikawa, Daisuke</creatorcontrib><title>Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patients with gastric cancer. In addition, the mechanisms underlying the effect of postoperative complications on outcomes remain to be elucidated. We hypothesized that immunosuppression by postoperative complications may affect long-term outcomes in patients with esophageal cancer.
Methods
In this retrospective study, we assessed in 153 patients with esophageal cancer who underwent curative subtotal esophagectomy at our hospital and examined the correlation between postoperative complications, and multiple clinicopathological factors, and long-term outcomes with the patients stratified by total lymphocyte count (TLC).
Results
The median preoperative TLC was 1432. A total of 115 patients (75.2%) had a TLC of ≥ 1000/μL (high TLC group), and the remaining 38 patients (24.8%) had a TLC of < 1000/μL (low TLC group). Postoperative complications occurred in 39 of 153 cases (25.5%). There was no significant correlation between postoperative complications and any of the clinicopathological factors in either group. In the high TLC group, patients with postoperative complications had significantly lower overall and disease-free survival rates compared with those without complications (
p
< 0.001 and
p
< 0.01, respectively). In the low TLC group, no survival difference between patients with and without postoperative complications was observed.
Conclusions
Postoperative complications may have a minimal impact on long-term outcomes in immunodeficient patients.</description><subject>Cell number</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy - adverse effects</subject><subject>Esophagus</subject><subject>Gastrectomy</subject><subject>Gastrectomy - adverse effects</subject><subject>Gastric cancer</subject><subject>Humans</subject><subject>Immunodeficiency</subject><subject>Immunosuppression</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative period</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Splenectomy</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Thoracic Oncology</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU9v1DAQxSMEon-_AAdkiQuXwDi2E-eIVoVW2qp72LvlOJNdV4kd7ATUb8_AFpA4cBr7-TdvbL-ieMPhA6-k-pg5SCFLqKAETUKpXxTnXJEka81f0hpqXbZVrc6Ki5wfAXgjQL0uzkQFUkML58XTLuYlzpjs4r8h28RpHr2jTQyZHS1J9z74yY7sbpqtW1gMbBvDodxjmtguxUOI2WfmAwHTGmKPg3cew8J25EI1s-9-ObKbHOejPSA5bWxwmK6KV4MdM14_18ti__lmv7kttw9f7jaftqUTjVpKBNFy6ETVdk7JAXnVDIOj97tukFa2TW9BIfYCh6bRUnKLTQdto3vXCD2Iy-L9yXZO8euKeTGTzw7H0QaMazaVUJIrqFVN6Lt_0Me4pkCXM5XkZAmaC6KqE-VSzDnhYOZEH5SeDAfzMxdzysVQLuZXLkZT09tn67WbsP_T8jsIAsQJyHQUDpj-zv6P7Q8Zx5nn</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Maruyama, Suguru</creator><creator>Kawaguchi, Yoshihiko</creator><creator>Akaike, Hidenori</creator><creator>Shoda, Katsutoshi</creator><creator>Saito, Ryo</creator><creator>Shimizu, Hiroki</creator><creator>Furuya, Shinji</creator><creator>Hosomura, Naohiro</creator><creator>Amemiya, Hidetake</creator><creator>Kawaida, Hiromichi</creator><creator>Sudo, Makoto</creator><creator>Inoue, Shingo</creator><creator>Kono, Hiroshi</creator><creator>Ichikawa, Daisuke</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200801</creationdate><title>Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer</title><author>Maruyama, Suguru ; Kawaguchi, Yoshihiko ; Akaike, Hidenori ; Shoda, Katsutoshi ; Saito, Ryo ; Shimizu, Hiroki ; Furuya, Shinji ; Hosomura, Naohiro ; Amemiya, Hidetake ; Kawaida, Hiromichi ; Sudo, Makoto ; Inoue, Shingo ; Kono, Hiroshi ; Ichikawa, Daisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e03910b329bc54fe127ffc124cbf4a497da05eed3ef778441ae7b0978dc738f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cell number</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy - adverse effects</topic><topic>Esophagus</topic><topic>Gastrectomy</topic><topic>Gastrectomy - adverse effects</topic><topic>Gastric cancer</topic><topic>Humans</topic><topic>Immunodeficiency</topic><topic>Immunosuppression</topic><topic>Lymphocytes</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative period</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Splenectomy</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Thoracic Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maruyama, Suguru</creatorcontrib><creatorcontrib>Kawaguchi, Yoshihiko</creatorcontrib><creatorcontrib>Akaike, Hidenori</creatorcontrib><creatorcontrib>Shoda, Katsutoshi</creatorcontrib><creatorcontrib>Saito, Ryo</creatorcontrib><creatorcontrib>Shimizu, Hiroki</creatorcontrib><creatorcontrib>Furuya, Shinji</creatorcontrib><creatorcontrib>Hosomura, Naohiro</creatorcontrib><creatorcontrib>Amemiya, Hidetake</creatorcontrib><creatorcontrib>Kawaida, Hiromichi</creatorcontrib><creatorcontrib>Sudo, Makoto</creatorcontrib><creatorcontrib>Inoue, Shingo</creatorcontrib><creatorcontrib>Kono, Hiroshi</creatorcontrib><creatorcontrib>Ichikawa, Daisuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maruyama, Suguru</au><au>Kawaguchi, Yoshihiko</au><au>Akaike, Hidenori</au><au>Shoda, Katsutoshi</au><au>Saito, Ryo</au><au>Shimizu, Hiroki</au><au>Furuya, Shinji</au><au>Hosomura, Naohiro</au><au>Amemiya, Hidetake</au><au>Kawaida, Hiromichi</au><au>Sudo, Makoto</au><au>Inoue, Shingo</au><au>Kono, Hiroshi</au><au>Ichikawa, Daisuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>27</volume><issue>8</issue><spage>3064</spage><epage>3070</epage><pages>3064-3070</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patients with gastric cancer. In addition, the mechanisms underlying the effect of postoperative complications on outcomes remain to be elucidated. We hypothesized that immunosuppression by postoperative complications may affect long-term outcomes in patients with esophageal cancer.
Methods
In this retrospective study, we assessed in 153 patients with esophageal cancer who underwent curative subtotal esophagectomy at our hospital and examined the correlation between postoperative complications, and multiple clinicopathological factors, and long-term outcomes with the patients stratified by total lymphocyte count (TLC).
Results
The median preoperative TLC was 1432. A total of 115 patients (75.2%) had a TLC of ≥ 1000/μL (high TLC group), and the remaining 38 patients (24.8%) had a TLC of < 1000/μL (low TLC group). Postoperative complications occurred in 39 of 153 cases (25.5%). There was no significant correlation between postoperative complications and any of the clinicopathological factors in either group. In the high TLC group, patients with postoperative complications had significantly lower overall and disease-free survival rates compared with those without complications (
p
< 0.001 and
p
< 0.01, respectively). In the low TLC group, no survival difference between patients with and without postoperative complications was observed.
Conclusions
Postoperative complications may have a minimal impact on long-term outcomes in immunodeficient patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32048090</pmid><doi>10.1245/s10434-020-08245-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Annals of surgical oncology, 2020-08, Vol.27 (8), p.3064-3070 |
| issn | 1068-9265 1534-4681 |
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| source | Springer Nature |
| subjects | Cell number Esophageal cancer Esophageal Neoplasms - surgery Esophagectomy - adverse effects Esophagus Gastrectomy Gastrectomy - adverse effects Gastric cancer Humans Immunodeficiency Immunosuppression Lymphocytes Medical prognosis Medicine Medicine & Public Health Oncology Postoperative Complications - etiology Postoperative period Prognosis Retrospective Studies Splenectomy Stomach Neoplasms - surgery Surgery Surgical Oncology Survival Rate Thoracic Oncology |
| title | Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer |
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