Loading…
Review: Insulin resistance and mitochondrial dysfunction following severe burn injury
•Insulin resistance occurs commonly following severe injury.•Mechanisms include increased stress hormones, catecholamines and cytokines.•Serine phosphylation of IRS-1 is an important regulatory element.•Mitochondrial dysfunction and lysis contribute to the inflammatory cascade.•Understanding pathoph...
Saved in:
Published in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2020-04, Vol.126, p.170269-170269, Article 170269 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c368t-cbffd0d0af19afcd46745eacef9f2103e39ff50059cfde7b969529c84c016ba43 |
---|---|
cites | cdi_FETCH-LOGICAL-c368t-cbffd0d0af19afcd46745eacef9f2103e39ff50059cfde7b969529c84c016ba43 |
container_end_page | 170269 |
container_issue | |
container_start_page | 170269 |
container_title | Peptides (New York, N.Y. : 1980) |
container_volume | 126 |
creator | Berlanga-Acosta, Jorge Iglesias-Marichal, Ileidys Rodríguez-Rodríguez, Nadia Mendoza-Marí, Yssel García-Ojalvo, Ariana Fernández-Mayola, Maday Playford, Raymond J. |
description | •Insulin resistance occurs commonly following severe injury.•Mechanisms include increased stress hormones, catecholamines and cytokines.•Serine phosphylation of IRS-1 is an important regulatory element.•Mitochondrial dysfunction and lysis contribute to the inflammatory cascade.•Understanding pathophysiology of IR provides new therapeutic opportunities.
The insulin signaling pathway plays a pivotal role in glucose metabolism and metabolic homeostasis. Disruption of this pathway is commonly seen in critical illness such as following severe burn injuries where homeostatic control is lost, leading to “insulin resistance” with poor blood glucose control. The aberrant signaling pathways involved in insulin resistance following burn injury include increases in hyperglycemic stress hormones, pro-inflammatory cytokines and free radical production. Leakage of mitochondrial sequestered self-antigens and signaling between mitochondria and endoplasmic reticulum also contribute to insulin resistance. Greater understanding of molecular processes involved in burn-related insulin resistance could potentially lead to the development of novel therapeutic approaches to improve patient management. |
doi_str_mv | 10.1016/j.peptides.2020.170269 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2354194470</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196978120300188</els_id><sourcerecordid>2354194470</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-cbffd0d0af19afcd46745eacef9f2103e39ff50059cfde7b969529c84c016ba43</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMouq7-BcnRS9ekTdPGkyJ-wYIg7jmkyURT2mRNWpf993ZZ9eppYHjeeZkHoQtKFpRQftUu1rAenIG0yEk-LSuSc3GAZrSuiqykXByiGaGCZ6Kq6Qk6TaklhDAm6mN0UuSElTynM7R6hS8Hm2v87NPYOY8jJJcG5TVg5Q3u3RD0R_AmOtVhs0129HpwwWMbui5snH_HCb4gAm7G6LHz7Ri3Z-jIqi7B-c-co9XD_dvdU7Z8eXy-u11muuD1kOnGWkMMUZYKZbVhvGIlKA1W2JySAgphbUlIKbQ1UDWCizIXumZ6UtAoVszR5f7uOobPEdIge5c0dJ3yEMYk86JkVDBWkQnle1THkFIEK9fR9SpuJSVyp1S28lep3CmVe6VT8OKnY2x6MH-xX4cTcLMHYPp0khll0g4mgcZF0IM0wf3X8Q3nwY22</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2354194470</pqid></control><display><type>article</type><title>Review: Insulin resistance and mitochondrial dysfunction following severe burn injury</title><source>ScienceDirect Freedom Collection</source><creator>Berlanga-Acosta, Jorge ; Iglesias-Marichal, Ileidys ; Rodríguez-Rodríguez, Nadia ; Mendoza-Marí, Yssel ; García-Ojalvo, Ariana ; Fernández-Mayola, Maday ; Playford, Raymond J.</creator><creatorcontrib>Berlanga-Acosta, Jorge ; Iglesias-Marichal, Ileidys ; Rodríguez-Rodríguez, Nadia ; Mendoza-Marí, Yssel ; García-Ojalvo, Ariana ; Fernández-Mayola, Maday ; Playford, Raymond J.</creatorcontrib><description>•Insulin resistance occurs commonly following severe injury.•Mechanisms include increased stress hormones, catecholamines and cytokines.•Serine phosphylation of IRS-1 is an important regulatory element.•Mitochondrial dysfunction and lysis contribute to the inflammatory cascade.•Understanding pathophysiology of IR provides new therapeutic opportunities.
The insulin signaling pathway plays a pivotal role in glucose metabolism and metabolic homeostasis. Disruption of this pathway is commonly seen in critical illness such as following severe burn injuries where homeostatic control is lost, leading to “insulin resistance” with poor blood glucose control. The aberrant signaling pathways involved in insulin resistance following burn injury include increases in hyperglycemic stress hormones, pro-inflammatory cytokines and free radical production. Leakage of mitochondrial sequestered self-antigens and signaling between mitochondria and endoplasmic reticulum also contribute to insulin resistance. Greater understanding of molecular processes involved in burn-related insulin resistance could potentially lead to the development of novel therapeutic approaches to improve patient management.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2020.170269</identifier><identifier>PMID: 32045621</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Burn injury ; Burns - metabolism ; Humans ; Hyperglycemia ; Hyperglycemia - metabolism ; Hyperglycemia - pathology ; Insulin ; Insulin receptor ; Insulin Resistance ; Mitochondria ; Mitochondria - pathology</subject><ispartof>Peptides (New York, N.Y. : 1980), 2020-04, Vol.126, p.170269-170269, Article 170269</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-cbffd0d0af19afcd46745eacef9f2103e39ff50059cfde7b969529c84c016ba43</citedby><cites>FETCH-LOGICAL-c368t-cbffd0d0af19afcd46745eacef9f2103e39ff50059cfde7b969529c84c016ba43</cites><orcidid>0000-0002-2788-0701</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32045621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berlanga-Acosta, Jorge</creatorcontrib><creatorcontrib>Iglesias-Marichal, Ileidys</creatorcontrib><creatorcontrib>Rodríguez-Rodríguez, Nadia</creatorcontrib><creatorcontrib>Mendoza-Marí, Yssel</creatorcontrib><creatorcontrib>García-Ojalvo, Ariana</creatorcontrib><creatorcontrib>Fernández-Mayola, Maday</creatorcontrib><creatorcontrib>Playford, Raymond J.</creatorcontrib><title>Review: Insulin resistance and mitochondrial dysfunction following severe burn injury</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>•Insulin resistance occurs commonly following severe injury.•Mechanisms include increased stress hormones, catecholamines and cytokines.•Serine phosphylation of IRS-1 is an important regulatory element.•Mitochondrial dysfunction and lysis contribute to the inflammatory cascade.•Understanding pathophysiology of IR provides new therapeutic opportunities.
The insulin signaling pathway plays a pivotal role in glucose metabolism and metabolic homeostasis. Disruption of this pathway is commonly seen in critical illness such as following severe burn injuries where homeostatic control is lost, leading to “insulin resistance” with poor blood glucose control. The aberrant signaling pathways involved in insulin resistance following burn injury include increases in hyperglycemic stress hormones, pro-inflammatory cytokines and free radical production. Leakage of mitochondrial sequestered self-antigens and signaling between mitochondria and endoplasmic reticulum also contribute to insulin resistance. Greater understanding of molecular processes involved in burn-related insulin resistance could potentially lead to the development of novel therapeutic approaches to improve patient management.</description><subject>Animals</subject><subject>Burn injury</subject><subject>Burns - metabolism</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - metabolism</subject><subject>Hyperglycemia - pathology</subject><subject>Insulin</subject><subject>Insulin receptor</subject><subject>Insulin Resistance</subject><subject>Mitochondria</subject><subject>Mitochondria - pathology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhoMouq7-BcnRS9ekTdPGkyJ-wYIg7jmkyURT2mRNWpf993ZZ9eppYHjeeZkHoQtKFpRQftUu1rAenIG0yEk-LSuSc3GAZrSuiqykXByiGaGCZ6Kq6Qk6TaklhDAm6mN0UuSElTynM7R6hS8Hm2v87NPYOY8jJJcG5TVg5Q3u3RD0R_AmOtVhs0129HpwwWMbui5snH_HCb4gAm7G6LHz7Ri3Z-jIqi7B-c-co9XD_dvdU7Z8eXy-u11muuD1kOnGWkMMUZYKZbVhvGIlKA1W2JySAgphbUlIKbQ1UDWCizIXumZ6UtAoVszR5f7uOobPEdIge5c0dJ3yEMYk86JkVDBWkQnle1THkFIEK9fR9SpuJSVyp1S28lep3CmVe6VT8OKnY2x6MH-xX4cTcLMHYPp0khll0g4mgcZF0IM0wf3X8Q3nwY22</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Berlanga-Acosta, Jorge</creator><creator>Iglesias-Marichal, Ileidys</creator><creator>Rodríguez-Rodríguez, Nadia</creator><creator>Mendoza-Marí, Yssel</creator><creator>García-Ojalvo, Ariana</creator><creator>Fernández-Mayola, Maday</creator><creator>Playford, Raymond J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2788-0701</orcidid></search><sort><creationdate>202004</creationdate><title>Review: Insulin resistance and mitochondrial dysfunction following severe burn injury</title><author>Berlanga-Acosta, Jorge ; Iglesias-Marichal, Ileidys ; Rodríguez-Rodríguez, Nadia ; Mendoza-Marí, Yssel ; García-Ojalvo, Ariana ; Fernández-Mayola, Maday ; Playford, Raymond J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-cbffd0d0af19afcd46745eacef9f2103e39ff50059cfde7b969529c84c016ba43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Burn injury</topic><topic>Burns - metabolism</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - metabolism</topic><topic>Hyperglycemia - pathology</topic><topic>Insulin</topic><topic>Insulin receptor</topic><topic>Insulin Resistance</topic><topic>Mitochondria</topic><topic>Mitochondria - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berlanga-Acosta, Jorge</creatorcontrib><creatorcontrib>Iglesias-Marichal, Ileidys</creatorcontrib><creatorcontrib>Rodríguez-Rodríguez, Nadia</creatorcontrib><creatorcontrib>Mendoza-Marí, Yssel</creatorcontrib><creatorcontrib>García-Ojalvo, Ariana</creatorcontrib><creatorcontrib>Fernández-Mayola, Maday</creatorcontrib><creatorcontrib>Playford, Raymond J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berlanga-Acosta, Jorge</au><au>Iglesias-Marichal, Ileidys</au><au>Rodríguez-Rodríguez, Nadia</au><au>Mendoza-Marí, Yssel</au><au>García-Ojalvo, Ariana</au><au>Fernández-Mayola, Maday</au><au>Playford, Raymond J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Review: Insulin resistance and mitochondrial dysfunction following severe burn injury</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2020-04</date><risdate>2020</risdate><volume>126</volume><spage>170269</spage><epage>170269</epage><pages>170269-170269</pages><artnum>170269</artnum><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>•Insulin resistance occurs commonly following severe injury.•Mechanisms include increased stress hormones, catecholamines and cytokines.•Serine phosphylation of IRS-1 is an important regulatory element.•Mitochondrial dysfunction and lysis contribute to the inflammatory cascade.•Understanding pathophysiology of IR provides new therapeutic opportunities.
The insulin signaling pathway plays a pivotal role in glucose metabolism and metabolic homeostasis. Disruption of this pathway is commonly seen in critical illness such as following severe burn injuries where homeostatic control is lost, leading to “insulin resistance” with poor blood glucose control. The aberrant signaling pathways involved in insulin resistance following burn injury include increases in hyperglycemic stress hormones, pro-inflammatory cytokines and free radical production. Leakage of mitochondrial sequestered self-antigens and signaling between mitochondria and endoplasmic reticulum also contribute to insulin resistance. Greater understanding of molecular processes involved in burn-related insulin resistance could potentially lead to the development of novel therapeutic approaches to improve patient management.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32045621</pmid><doi>10.1016/j.peptides.2020.170269</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2788-0701</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0196-9781 |
ispartof | Peptides (New York, N.Y. : 1980), 2020-04, Vol.126, p.170269-170269, Article 170269 |
issn | 0196-9781 1873-5169 |
language | eng |
recordid | cdi_proquest_miscellaneous_2354194470 |
source | ScienceDirect Freedom Collection |
subjects | Animals Burn injury Burns - metabolism Humans Hyperglycemia Hyperglycemia - metabolism Hyperglycemia - pathology Insulin Insulin receptor Insulin Resistance Mitochondria Mitochondria - pathology |
title | Review: Insulin resistance and mitochondrial dysfunction following severe burn injury |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T13%3A49%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Review:%20Insulin%20resistance%20and%20mitochondrial%20dysfunction%20following%20severe%20burn%20injury&rft.jtitle=Peptides%20(New%20York,%20N.Y.%20:%201980)&rft.au=Berlanga-Acosta,%20Jorge&rft.date=2020-04&rft.volume=126&rft.spage=170269&rft.epage=170269&rft.pages=170269-170269&rft.artnum=170269&rft.issn=0196-9781&rft.eissn=1873-5169&rft_id=info:doi/10.1016/j.peptides.2020.170269&rft_dat=%3Cproquest_cross%3E2354194470%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c368t-cbffd0d0af19afcd46745eacef9f2103e39ff50059cfde7b969529c84c016ba43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2354194470&rft_id=info:pmid/32045621&rfr_iscdi=true |