Role of regulatory miRNAs of the PI3K/AKT signaling pathway in the pathogenesis of breast cancer

• Published in: Gene 2020-05, Vol.737, p.144459-144459, Article 144459
• Main Authors: Rahmani, Farzad, Ferns, Gordon A, Talebian, Sahar, Nourbakhsh, Mahnaz, Avan, Amir, Shahidsales, Soodabeh
• Format: Article
• Language: English
• Subjects: Breast cancer; Breast Neoplasms - enzymology; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cell Movement - genetics; Cell Proliferation - genetics; Female; Genes, Tumor Suppressor; Humans; MicroRNA; MicroRNAs - physiology; Neoplasm Metastasis - genetics; Phosphatidylinositol 3-Kinases - metabolism; PI3K/AKT signaling; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; TOR Serine-Threonine Kinases - metabolism
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2020.144459

•Aberrant activity of PI3K pathway is related to tumor metastasis in breast cancer.•miRNAs have implicated in breast cancer cell growth, migration and metastasis.•Regulation of oncogenic miRNAs have pivotal roles in management of breast cancer. Breast cancer is one of the most common tumors in women. Current data indicate that the overexpression of some microRNAs (miRNAs) is associated with breast cancer, in relation to stage, tumor size and potential for metastasis. Some studies have reported that miRNAs have critical roles in cellular processes implicated in breast cancer cell growth, migration and metastasis by targeting the PI3K/AKT oncogenic signaling pathway. Therefore, identifying novel regulatory miRNAs for this oncogenic pathway and discovery of their related target genes may represent a promising therapeutic approach for breast cancer therapy. This review highlights the recent findings about the potential role of PI3K/AKT signaling regulatory miRNAs in breast cancer tumorigenesis.