Titanium Alkoxide-Based Regioselective Alkyne–Alkyne Reductive Coupling Mediated by In Situ Generated Arylamidate

Titanium alkoxide-based alkyne–alkyne reductive coupling mediated by in situ generated arylamidate is described. A high level of regioselectivity is achieved in 37 examples, where (E,E)-dienes are exclusively formed. To the best of our knowledge, this study represents the first example of an apparen...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2020-02, Vol.142 (8), p.3729-3735
Main Authors: Cai, Bin, Panek, James S
Format: Article
Language:English
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Summary:Titanium alkoxide-based alkyne–alkyne reductive coupling mediated by in situ generated arylamidate is described. A high level of regioselectivity is achieved in 37 examples, where (E,E)-dienes are exclusively formed. To the best of our knowledge, this study represents the first example of an apparent amide and carbamate directing effect in metal-mediated reductive coupling.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.0c00550